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TranscriptomicsDNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm
Background: Prenatal maternal stress (PNMS) predicts a wide variety of behavioral and physical outcomes in the offspring. Although epigenetic processes may be responsible for PNMS effects, human research is hampered by the lack of experimental methods that parallel controlled animal studies. Disaste...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-72354 | biostudies-arrayexpress
TranscriptomicsRole of DNA Methylation in the Nucleus Accumbens in Incubation of Cocaine Craving
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66350 | biostudies-arrayexpress
TranscriptomicsStilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity
Genome wide DNA methylation profiling of human breast cancer cell lines, lowly invasive MCF10CA1h and highly invasive MCF10CA1a, treated with vehicle control (ethanol) and with RSV (resveratrol). The Illumina Infinium 450K Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profil...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80794 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-12-11 | E-GEOD-53193 | biostudies-arrayexpress
TranscriptomicsThe landscape of promoter DNA hypomethylation in liver cancer
This SuperSeries is composed of the following subset Series: GSE29720: The landscape of promoter DNA hypomethylation in liver cancer (MeDIP-chip data) GSE29721: The landscape of promoter DNA hypomethylation in liver cancer (expression data) Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-06-04 | E-GEOD-29722 | biostudies-arrayexpress
TranscriptomicsBroad epigenetic signature of maternal care in the brain of adult rats
This SuperSeries is composed of the following subset Series: GSE20714: Broad epigenetic signature of maternal care in the brain of adult rats (DNA methylation and H3K9 acetylation profiles) GSE20717: Broad epigenetic signature of maternal care in the brain of adult rats (expression) Refer to individ...
ORGANISM(S): Rattus norvegicus 
2011-03-09 | E-GEOD-20840 | biostudies-arrayexpress
GenomicsDNA methylation at transcription start sites blocks TBP binding and transcription onset by RNApolII [ChIPbisSeq]
We report the application of ChIP bisulfite sequencing (ChIPbisSeq) to establish the methylation state of DNA bound to RNApol2 phosphorylated in Ser5 (RNAPol2Ser5) in the mouse cortex. We first profiled the RNAPol2Ser5 binding using regular ChIPSeq from 45 million raw read pairs (31 million unique p...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-60657 | biostudies-arrayexpress
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving and treatments with DNA methylation modifying drugs
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine, were subjected to 30 withdrawal days, were treated with aCSF, RG108 or SAM and were subjected to extinction tests. The groups consist of: 1. Rats that self-administered cocaine for 10 days and that were subjected...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66347 | biostudies-arrayexpress
TranscriptomicsDNA methylation at transcription start sites blocks TBP binding and transcription onset by RNApolII [MeDIP]
We measured the methylation levels of gene promoters of cerebral cortex of mice. We used MeDIP-array, immunoprecipitating genomic DNA with an antibody against methylated DNA and measuring methylation levels using custom arrays. The input DNA was used as control. triplicates of frontal cortex DNA po...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-60656 | biostudies-arrayexpress
TranscriptomicsEarly life adversity alters normal sex-dependent developmental dynamics of DNA methylation in rhesus monkeys
This study mapped the genome wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through two years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles ev...
ORGANISM(S): Macaca mulatta 
2016-07-06 | E-GEOD-84024 | biostudies-arrayexpress
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