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TranscriptomicsRNA-seq analysis of gene expression in male and female mouse liver
Gene expression in adult male and female mouse liver assayed by RNA-seq, as part of a study on chromatin states in male and female mouse and their role in sex-biased liver gene expression (A Sugathan and DJ Waxman (2013) Molec Cell Biol, in press). Total liver RNA was prepared from 12 individual mal...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-48109 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modifications in male and female mouse liver
Here we map six chromatin modifications -- H3K4me1, H3K4me3, H3K27ac, H3K36me3, H3K9me3, and H3K27me3 -- genome-wide in male and female mouse liver in order to identify histone modifications that characterize sex-biased genes and sex-biased DNase hypersensitive sites and their regulation by plasma g...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-44571 | biostudies-arrayexpress
GenomicsUnbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and diseas...
ORGANISM(S): Mus musculus 
2010-09-28 | E-GEOD-21777 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease
Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical power. 1,249 sex-biased genes were identified, 70% showing higher expression in females. Chromo...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-23766 | biostudies-arrayexpress
TranscriptomicsCHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [RNA-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61491 | biostudies-arrayexpress
GenomicsCHD8M-BM- regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [ChIP-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61487 | biostudies-arrayexpress
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