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TranscriptomicsGenome-wide profiling of Su(H) in Drosophila melanogaster Kc167 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66226 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of Su(H) in Drosophila melanogaster BG3 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66225 | biostudies-arrayexpress
TranscriptomicsChIP-chip time-course from DmD8 cells with Su(H) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the N...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35719 | biostudies-arrayexpress
TranscriptomicsSu(H) bound regions in Su(H) induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41425 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of Su(H) [CSL] binding in Drosophila melanogaster larval CNSs where Notch is hyperactive in neuroblasts for 24 hours
The Notch pathway is a well conserved cell to cell communication mechanism that is normally involved in many developmental processes and when aberrantly activated it leads to diseases such as cancer. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Dros...
ORGANISM(S): Drosophila melanogaster 
2015-12-15 | E-GEOD-68614 | biostudies-arrayexpress
GenomicsSu(H)_Kc_cells_ChIP-seq
modENCODE_submission_5018 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-12-21 | E-GEOD-53561 | biostudies-arrayexpress
GenomicsSu(H)_0-8_embryonic_ChIP-seq
modENCODE_submission_5017 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-08-11 | E-GEOD-49776 | biostudies-arrayexpress
GenomicsSu(H)_8-16h_embryo_ChIP-seq
modENCODE_submission_4068 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of all the Transcription Factors (TF) on the genome of Drosophila melanogaster...
ORGANISM(S): Drosophila melanogaster 
2013-08-28 | E-GEOD-50337 | biostudies-arrayexpress
TranscriptomicsSu(H) bound regions in Nicd induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41426 | biostudies-arrayexpress
TranscriptomicsGene expression changes in Su(H) induced wing disc hyperplasia
The outcome of Notch activation of proliferation depends on cellular context. In Drosophila wing discs Notch pathway overactivation results in hyperplasia. To understand the mechanisms we have used genomic strategies to indetify the Notch-S(H) target genes directly regulated in wing disc hyperplasia...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41427 | biostudies-arrayexpress
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