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ProteomicsThe combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
Exosomes from pancreatic cancer-associated fibroblasts and mesenchymal stem cells that have been transduced with the yeast cytosine deaminase::uracil phosphoribosyl transferase release suicide gene exosomes acting as "Trojan horse" drugs, effectively killing pancreatic cancer cells by converting the...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD059055 | Pride
Pancreatic cancer-associated fibroblasts Mesenchymal stem cells Gene-directed enzyme prodrug therapy Pancreatic cancer intracellular treatment Suicide gene exosomes 
ProteomicsMass spectrometry based identification of similarities and differences in protein content of cutaneous melanoma cell lines and exosomes
Intercellular transport of proteins mediated by extracellular vesicles (EVs) exosomes and ectosomes, is one of the factors facilitating carcinogenesis. Therefore, the research on protein cargo of melanoma-derived EVs may provide a better understanding of mechanisms related to melanoma progression an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-15 | MSV000090907 | MassIVE
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 3
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080268 | MassIVE
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 4
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. The concentrations of these proteins are combined in the Anti Apoptotic index (AAI). We previously found that th...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080266 | MassIVE
UnknownSuicide gene therapy by canine mesenchymal stem cell transduced with thymidine kinase in a u-87 glioblastoma murine model: Secretory profile and antitumor activity.
Not available
S-EPMC8846542 | biostudies-literature
ProteomicsMass spectrometry-based proteomic characterization of cutaneous melanoma ectosomes reveals the presence of cancer-related molecules
Cutaneous melanoma (CM) is an aggressive type of skin cancer for which effective biomarkers are still needed. Due to the development of protocols for their successful isolation, protein content of extracellular vesicles (EVs) (including ectosomes and exosomes) became increasingly investigated in ter...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-03 | MSV000084892 | MassIVE
ProteomicsExosomes from GBM established cell lines (U87, U373) and GBM primary CSC
In this study, we investigated and compared the miRNA and protein content of the small EVs released by different human GBM established cell lines and by GBM primary CSC lines, to explore the role of EVs in their different tumor behavior and capacities.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-11 | MSV000088671 | MassIVE
TranscriptomicsRNA-seq of Pacific oyster Crassostrea gigas under different developmental stages and stress treatments
Deep sequencing of samples from different development stages, different adult organs and different stress treatments of Pacific oyster Crassostrea gigas Samples of 38 developmental stages from egg to juvenile were analyzed using single-end 49 bp RNA-seq. Two libraries mixed by RNAs from different de...
ORGANISM(S): Crassostrea gigas 
2012-09-13 | E-GEOD-31012 | biostudies-arrayexpress
TranscriptomicsCharacterization of the miRNA profile of activated or apoptotic lymphocytes and corresponding released microvesicles in normal healthy donors and systemic lupus erythematosus (SLE) patients.
In this experiment, the miRNA profile of microvesicles (MV) released from activated or apoptotic (UV-B treated) T-lymphocytes and their cells of origin was analyzed in both samples obtained from normal healthy donors and systemic lupus erythematosus (SLE) patients. Therefore in short, RNA was isolat...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-3944 | biostudies-arrayexpress
ProteomicsAutophagic stress activates two distinct compensatory secretory pathways in neurons
Neurons are reliant on autophagy to constitutively degrade damaged proteins and organelles in order to maintain cellular homeostasis. Autophagic dysfunction is associated with neurodegenerative diseases including Parkinson Disease. Mutations in the kinase LRRK2 are one of the most common causes of f...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-24 | MSV000095428 | MassIVE
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