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TranscriptomicsT cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T cell-intrinsic expres...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-85131 | biostudies-arrayexpress
TranscriptomicsExpression data analyzing ID3 (Inhibitor of DNA binding 3)-affected mouse T cells
Mouse CD8+ T cells affected by ID3 (Inhibitor of DNA binding 3) display patterns of gene expression suggesting enhanced persistance and survival. In this study, we identified genes differentially expressed between ID32a transduced and mock transduced, and ID32a knockout and wild type mouse CD8+ T ce...
ORGANISM(S): Mus musculus 
2011-10-15 | E-GEOD-23568 | biostudies-arrayexpress
TranscriptomicsCD8+ T-cell memory bears the transcriptional imprint of progressive differentiation
The generation of CD8+ T-cell memory is an important aim of immunization. While several distinct subsets of CD8+ T-cell memory have been described, the lineage relationships between effector (EFF), effector memory (EM) and central memory (CM) T cells remain contentious. Specifically, there is contra...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42459 | biostudies-arrayexpress
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