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ProteomicsUncovering Global SUMOylation Signaling Networks in a Site-Specific Manner
SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution mass spectrometry, we have studied global SUMOylation in mammalian cells and in a site-specific manner, identifying a total of over 4,300 SUMOylation sites in over 1,600 proteins. Moreov...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080793 | MassIVE
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in HEK293 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54109 | biostudies-arrayexpress
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in PC-3 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54110 | biostudies-arrayexpress
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080754 | MassIVE
TranscriptomicsDisrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease
Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification th...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-60691 | biostudies-arrayexpress
TranscriptomicsElectrophilic lipid mediator 15-deoxy-M-NM-^T12,14-prostaglandin J2 modifies glucocorticoid signaling via receptor SUMOylation
Cortisol, the central stress hormone in humans, activates the glucocorticoid receptor (GR). Anti-inflammatory effects are the most important pharmaceutical effects mediated by the GR. Inasmuch as electrophilic cyclopentenone prostaglandin 15-deoxy-M-NM-^T12,14-prostaglandin J2 (15d-PGJ2) has potent ...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-54087 | biostudies-arrayexpress
OtherSUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
Data from ProteomeXchange, PXD ID: PXD001681. File: RGP-HA-mSLX4-coIP-Control-1b.mzml. Published as part of EMBO Rep. 2015 Feb 26 . From the Abstract: {{i}} ... We report that the SLX4 nuclease scaffold protein is regulated by SUMOylation. We have identified three SUMO interaction motifs (SIMs) in ...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310007055 | GPMDB
Resource Reanalysis 
ProteomicsSystem-Wide Identification of Wild-Type SUMO-2 Conjugation Sites
SUMOylation is a reversible post-translational modification regulating all nuclear processes. Identification of SUMOylation sites by mass spectrometry has been hampered by bulky tryptic fragments, which thus far necessitated the use of mutated SUMO. Here, we present a dataset generated through a SUM...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080714 | MassIVE
TranscriptomicsSUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-48379 | biostudies-arrayexpress
Proteomicsinterferon-induced global cellular SUMOylation Changes
This proteomics dataset was generated to study the changes in SUMO site abundances between control cells and Interferon-alpha treated cells using SILAC. Cells were first fractionated into the cytoplasmic and nuclear fractions. SUMOylated proteins were then purified from these extracts by Ni-NTA via ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081525 | MassIVE
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