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GenomicsEpigenetic and genetic changes during mouse hematopoietic stem cell aging [Bisulfite-Seq]
To investigate the global DNA methylation changes in mouse hematopoietic stem cell aging, we performed whole-genome bisulfite sequencing (WGBS). We generated 1,494 million (4mo HSCs), and 1,493 million (24mo HSCs) raw reads; about 82.6% and 84.3%, respectively, were successfully aligned to either st...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-47815 | biostudies-arrayexpress
TranscriptomicsRole of de novo DNA methyltransferases in hematopoietic stem cells (RNA-seq)
To investigate the global transcriptome expression in Dnmt3ab dKO HSCs, we performed high-throughput sequencing of Poly A+ RNA (RNA-Seq) from purified HSCs (SP-KSL-CD150+). With biological duplicates, more than 200 million reads in total for each genotype of HSC were obtained. Mouse hematopoietic st...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50775 | biostudies-arrayexpress
GenomicsLong Non-coding RNAs Control Hematopoietic Stem Cell (HSC) Function
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-63277 | biostudies-arrayexpress
TranscriptomicsRole of de novo DNA methyltransferases in hematopoietic stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50793 | biostudies-arrayexpress
GenomicsGenome-wide analysis of RXRa binding in mouse liver chromatin with ChIP-SEQ.
For the genome-wide analysis using ChIP-Seq on mouse liver cells, a full accounting of all RXRα binding sites and of RXRa related gene regulations is expected to address the main knowledge gap around RXRα. Liver tissue of wild type and hs-RXRa-del-exon4-/- mice, male and female for each genotype h...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-21696 | biostudies-arrayexpress
GenomicsRole of de novo DNA methyltransferases in hematopoietic stem cells (WGBS)
To investigate the global DNA methylation changes in Dnmt3a-KO and Dnmt3ab-dKO HSCs compared to control HSCs, we performed whole genome bisulfite sequencing Mouse hematopoietic stem cell DNA methylation profiles of control, Dnmt3a-KO and Dnmt3ab-dKO HSCs were generated generated by deep sequencing,...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50780 | biostudies-arrayexpress
GenomicsThe Estrogen receptor alpha cistrome defined by DamIP
We have developed a new method to study DNA-protein interaction in vivo called DamIP, which is based on fusing a protein of interest to a mutant form of DNA adenine methylatransferase (Dam) from E. coli. We showed previously that DamIP can efficiently identify in vivo binding sites of Dam-tethered h...
ORGANISM(S): Homo sapiens 
2011-11-19 | E-GEOD-33804 | biostudies-arrayexpress
UnknownRrMYB5- and RrMYB10-regulated flavonoid biosynthesis plays a pivotal role in feedback loop responding to wounding and oxidation in Rosa rugosa.
Not available
S-EPMC6790370 | biostudies-literature
ProteomicsMolecular Landscape of Atherosclerotic Plaque Progression: Insights from Proteomics
This dataset comprises proteomic profiles of 87 human carotid atherosclerotic plaques from patients undergoing carotid endarterectomy (CEA). The study employed an integrated approach using Data Independent Acquisition (DIA) proteomics. A total of 87 human carotid plaques were analyzed to identify an...
ORGANISM(S): Homo Sapiens 
2025-03-26 | PXD062283 |
Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
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