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ProteomicsProteome of renal cell line caki-2 with AFMID overexpression and potential biomarker discovery in urine
Aromatic caninurine formamase (AFMID) is an enzyme involved in tryptophan pathway, metabolizing N-formylkynurenine to kynurenine. AFMID had been found significantly down regulated in clear cell renal cell carcinoma (ccRCC) in both tissue and urine samples. Although ccRCC is characterized by a typica...
ORGANISM(S): Homo Sapiens 
2024-07-28 | PXD054327 |
ProteomicsStandard operating procedure combined with comprehensive quality control system to enable large-scale urinary proteomics across multiple LC-MS platforms for precision medicine
In this study, we carried out a comprehensive evaluation of multiple LC-MS platforms in urinary proteomics including 756 proteome measurements. A series of interrelated studies was designed to assess the intra- and inter-platform consistency and reproducibility. First, we optimized the method for u...
ORGANISM(S): Homo Sapiens Escherichia Coli Saccharomyces Cerevisiae 
2024-10-28 | PXD050291 |
ProteomicsBlood and Urine-Based Liquid Biopsy for early stage cancer investigation: Taken Clear Renal Cell Carcinoma as A Model
We analyzed samples of tumor tissue, plasma, and urine from a cohort of 27 ccRCC patients with T1-2 stage and 27 matched healthy controls, using liquid chromatography–mass spectrometry (LC-MS) for proteomic analysis. We integrated the differential proteins found in the three types of samples to expl...
ORGANISM(S): Homo Sapiens 
2023-06-20 | PXD043118 |
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