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Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
The project aims to investigate the molecular mechanisms of aging by analyzing protein expression and modifications across various tissues in multiple organisms. Using advanced mass spectrometry, the project will collect and compare proteomic profiles from different organs at various ages. By identi...
ORGANISM(S): Mus Musculus 
2025-03-18 | PXD061948 |
Acute coronary syndrome (ACS) is a kind of cardiovascular disease caused by acute myocardial ischemia. The aim of this study was to use urine metabolomics to explore the potential biomarkers for the diagnosis of ACS and the changes in metabolites during the development of the disease.
ORGANISM(S): Homo Sapiens 
2024-12-03 | PXD058501 |
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation (LT); however, the potential mechanism remains unclear. Here, we demonstrated older livers exhibit a higher degree of ferroptosis during HIRI. Inhibiting ferro...
ORGANISM(S): Mus Musculus 
Diabetes retinopathy (DR) and diabetes kidney disease (DKD) are the complications of diabetes and causing serious health and economic burden to society. However, identification and characterization of early biomarkers for DKD, especially for non-proliferative DR (NPDR) patients with DKD, are still l...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036172 |
The size of plant lateral organs is determined by well-coordinated cell proliferation and cell expansion. Here, we report that miR159, an evolutionarily conserved microRNA, plays an essential role in regulating cell division in rose (Rosa hybrida) petals by modulating cytokinin catabolism. We uncove...
ORGANISM(S): Rosa Hybrid Cultivar 
2023-10-18 | PXD046197 |
In this project, we used label-free quantitative proteomics to identify proteins that are differentially regulated by indisulam in the gastric cancer AGS cell line.
ORGANISM(S): Homo Sapiens 
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