Sort   by:  
 Page size 
MetabolomicsCorpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))

Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal c...

2026-06-12 | MTBLS14754 | MetaboLights
TranscriptomicsExpression data from human skin exposed to solar-simulated radiation with or without sunscreen
Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscr...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22083 | biostudies-arrayexpress
UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
ProteomicsUnique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
RAC1P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1P29S mutations in melanoma and RAC1 alterations in several other c...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD046960 | Pride
Pd-1 Rac1 Melanoma Cdk9 
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsAnalysis of five species of Gossypium allotetraploids and a synthetic F1 hybrid compared to model diploid projenitors
We compare gene expression among petals tissues in 5 species of natural allotetraploid and F1 hybrid cottons to the antecedent conditions existing prior to genome merger and duplication, thus revealing the effects of genome merger and polyploidy on gene expression evolution 27 total samples, includ...
ORGANISM(S): Gossypium arboreum 
2009-09-01 | E-GEOD-17927 | biostudies-arrayexpress
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
ModelsBand2012_DII-Venus_FullModel
This model is from the article: Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. Band LR, Wells DM, Larrieu A, Sun J, Middleton AM, French AP, Brunoud G, Sato EM, Wilson MH, Péret B, Oliva M, Swarup R, Sairanen I,...
2024-09-02 | BIOMD0000000413 | BioModels
ModelsBand2012_DII-Venus_ReducedModel
This model is from the article: Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. Band LR, Wells DM, Larrieu A, Sun J, Middleton A...
2024-09-02 | BIOMD0000000414 | BioModels
TranscriptomicsNext-generation sequencing facilitates quantitative analysis of diaphysis and metaphysis from femur of 5-week-old Dlx3Oc-cKO and wild type (WT=Dlx3+/+) mice transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived femoral diaphysis and metaphysis transcriptome profiling (RNA-seq) to determine pathways and networks dependent on Dlx3 during bone development...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-53105 | biostudies-arrayexpress
Sort   by:  
 Page size