Sort   by:  
 Page size 
TranscriptomicsGenome-wide sequencing small RNAs in response to powdery mildew and heat stress in wheat
To test whether non-coding RNAs play roles in regulating response to powdery mildew infection and heat stress in wheat, by using Solexa high-throughput sequencing and computational analysis and experimental approach we cloned the small RNAs and identified 125 putative long npcRNAs from wheat leaves ...
ORGANISM(S): Triticum aestivum 
2011-02-15 | E-GEOD-27327 | biostudies-arrayexpress
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
TranscriptomicsDynamic Expression of Imprinted Genes Associates with Maternally Controlled Nutrient Allocation during Maize Endosperm Development
In angiosperms, the endosperm provides nutrients for embryogenesis or seed germination and is the primary tissue where gene imprinting occurs. To map the imprintome of the early developing endosperm in maize, we performed high-throughput transcriptome sequencing of the kernels at 0, 3, 5 days after ...
ORGANISM(S): Zea mays 
2013-06-29 | E-GEOD-48425 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsA protein-centric glycoproteomic strategy identifies site-specific glycans as robust diagnostic markers for hepatocellular carcinoma
In this study, we achieved the quantitative glycoproteomics analysis of a large cohort of clinical specimens including 100 Hepatocellular carcinoma (HCC) and 100 healthy control human serums by using an integrated platform.
ORGANISM(S): Homo Sapiens (human) 
2026-06-26 | PXD065283 | JPOST Repository
ProteomicsHlncRNA-1 integrates the hepatic circadian clock with lipid metabolism by targeting Hdlbp
The circadian rhythm and lipid metabolism in organisms are tightly coupled, yet the role of lncRNAs in the integration of these two important physiological processes remains unclear. In this study, we identified a liver-specific lncRNA named HlncRNA-1, which regulates lipid metabolism while respondi...
ORGANISM(S): Mus Musculus 
2026-03-16 | PXD075733 |
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
GenomicsA small cell lung cancer genome reports complex tobacco exposure signatures
Cancer is driven by mutation. Worldwide, tobacco smoking is the major lifestyle exposure that causes cancer, exerting carcinogenicity through 60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small cell lung cancer cell line, NCI-H209, to explore t...
EGAS00000000051 | EGA
ProteomicsPrelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity label...
ORGANISM(S): Homo Sapiens 
2024-01-31 | PXD049033 |
GenomicsEGAD00000000054
NCI-H209 is an immortal cell line derived from a bone marrow metastasis of a patient with small cell lung cancer, taken before chemotherapy. The specimen showed histologically typical small cells with classic neuroendocrine features. NCI-BL209 is an EBV-transformed B-cell line derived from the same ...
EGAD00000000054 | EGA
Sort   by:  
 Page size