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TranscriptomicsImpact of library preparation on downstream analysis and interpretation of RNA-seq data: comparison between Illumina PolyA and NuGEN Ovation protocol
Objectives: The sequencing by the PolyA selection is the most common approach for library preparation. With limited amount or degraded RNA, alternative protocols such as the NuGEN have been developed. However, it is not yet clear how the different library preparations affect the downstream analyses ...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-47933 | biostudies-arrayexpress
TranscriptomicsDeep Sequence Analysis of the Relationship between Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells
We used deep sequencinge technology to profile the transcriptome, gene copy number, and CpG island methylation status simultaneously in eight commonly used breast cell lines to develop a model for how these genomic features are integrated in estrogen receptor positive (ER+) and negative breast cance...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-27003 | biostudies-arrayexpress
TranscriptomicsDeep Sequence Analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations
In this manuscript, we have used RNA-Sequencing experiment to obtain and integrate a variety of genomic features in order to identify signaling pathways that are associated to mutant KRAS lung tumors. 8 lung adenocarcinomas with mutant KRAS in lung tumors and 8 lung adenocarcarcinomas without KRAS m...
ORGANISM(S): Homo sapiens 
2012-06-07 | E-GEOD-34914 | biostudies-arrayexpress
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
TranscriptomicsAn Integrated Model of the Transcriptome Landscape of HER2-Positive Breast Cancer
The goal of our study is to build an integrated transcriptome landscape model for HER2 positive breast tumors and identify the crucial signaling pathways associated with HER2 tumors. Genomic features include, 685 genes that were differentially expressed only in HER2-positive tumors, 102 genes that w...
ORGANISM(S): Homo sapiens 
2013-12-06 | E-GEOD-45419 | biostudies-arrayexpress
UnknownClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Not available
S-EPMC6193486 | biostudies-literature
UnknownImpact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries.
Not available
S-EPMC10783642 | biostudies-literature
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