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MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
ProteomicsN-linked glycoproteins from exosome-depleted excretory-secretory products of fourth-stage larval Angiostrongylus cantonensis promotes alternative activation of macrophages through metabolic reprogramming by the PI3K-Akt pathway
Angiostrongylus cantonensis (AC), which parasitizes in the brain of the non-permissive host, such as mouse and human, is an etiologic agent of eosinophilic meningitis. Excretory-secretory (ES) products play an important role in the interaction between parasites and hosts’ immune responses. Inflammat...
ORGANISM(S): Angiostrongylus cantonensis 
2021-07-28 | PXD025218 | Pride
Exosome-depleted excretory-secretory products N-linked glycoproteins Mechanism Angiostrongylus cantonensis Macrophage polarization 
UnknownZhuang Gu Guan Jie Wan: Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis Treatment.
Not available
S-EPMC6260402 | biostudies-literature
UnknownExploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer's disease.
Not available
S-EPMC9465410 | biostudies-literature
ProteomicsIdentification of human gene LOC107984012 interacting proteins in AC16 cardiomyocytes by pull-down assays coupled to MS
In this study, pull down assays combined with mass spectrometry analysis were performed in AC16 cardiomyocytes transfected with control plasmid (OE-Vector) or LOC107984012-overexpression plasmid to identify the repertoire of LOC107984012 interacting proteins. Pierce™ Magnetic RNA-Protein Pull-Down K...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037001 | Pride
Human gene loc107984012 
ProteomicsIdentification of mouse lncRNA ENSMUST00000219456(GM32255) interacting proteins in HL-1 cardiomyocytes by pull-down assays coupled to MS
In this study, pull down assays combined with mass spectrometry analysis were performed in HL-1 cardiomyocytes transfected with control plasmid (OE-Vector) or LOC107984012-overexpression plasmid to identify the repertoire of LOC107984012 interacting proteins.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD036966 | Pride
Mouse lncrna ensmust00000219456(gm32255) 
ProteomicsProteomic Analysis by iTRAQ-MRM of Soybean Resistance to Lamprosema Indicate
This study was conducted to: (1)comparative analysis of expression profiles of proteins in soybean leaf(a highly resistant line (Gantai-2-2) and a highly susceptible line (Wan 82-178) were exposed to Lamprosema indicate larval feedings for 0 h and 48 h);(2)explore how these proteins participated in ...
ORGANISM(S): Glycine max 
2018-10-26 | PXD004953 | Pride
Soybean  lamprosema indicate (fabricius)  itraq  mrm  differential expressed protein 
ProteomicsIntegrated multi-omic analysis of Mycobacterium tuberculosis isolates identifies ethionamide resistance-associated gene pair Rv3094c-Rv3095
Global control of the tuberculosis (TB) epidemic is seriously threatened by increasing prevalence of drug resistant (DR) M. tuberculosis (MTB) isolates. Many genome-wide studies have identified DR-associated SNPs and investigated their role in DR mechanisms. However, DR in ~30% of isolates has no cl...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2023-03-10 | PXD017079 | Pride
Transcriptome Mycobacterium tuberculosis Drug resistance Lineage Proteome Baeyer-villiger monooxygenase Phylogenetics Ethionamide Rna-seq 
UnknownPrognostic value of a novel biomarker combining DNA ploidy and tumor burden score for initially resectable liver metastases from patients with colorectal cancer.
Not available
S-EPMC8542290 | biostudies-literature
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