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ProteomicsLabel-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling
Label-free quantification is a powerful method for studying cellular protein phosphorylation dynamics. However, whether current data normalization methods achieve sufficient accuracy has not been examined systematically. Here, we demonstrate that a large uni-directional shift in the phosphopeptide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080775 | MassIVE
ProteomicsSimulated spectral library searching on TripleTOF phosphopeptide datasets
Synthetic phosphopeptides and enriched K562 cell phosphopeptides were analyzed using a TripleTOF 6600 mass spectrometer before and after enzymatic dephosphorylation. Dephosphorylated peptides identified by X!Tandem database searching were subjected to spectral simulation of all possible single phosp...
ORGANISM(S): Homo Sapiens (human) 
2019-12-03 | PXD012433 | JPOST Repository
TranscriptomicsRRBS (DNA methylation) analysis of CD4+ CD8+ and CD4-CD8- fractions of PBMC cells collected from 7 case children, who were positive for type 1 diabetes specific autoantibodies, and their matched controls, sampled at 3, 6, 12, 18, 24, and 36 months of age
10.1007/s00125-022-05657-x
ORGANISM(S): Homo sapiens 
2022-02-14 | E-MTAB-11088 | biostudies-arrayexpress
ProteomicsHeLa phosphoproteome regulated by PP2A related proteins
HeLa cells were treated with siRNAs of PP2A related proteins or with okadaic acid, in triplicates. Tryptic digests of extracted proteins were analyzed using a Q Exactive mass spectrometer, before and after TiO2 phosphopeptide enrichment. Data were searched with Mascot via Proteome Discoverer. For ph...
ORGANISM(S): Homo Sapiens (human) 
2020-02-19 | PXD016102 | JPOST Repository
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