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ProteomicsSuper-SILAC Allows Classification of Diffuse Large B-cell Lymphoma Subtypes by Their Protein Expression Profiles
Correct classification of cancer patients into subtypes is a prerequisite for acute diagnosis and effective treatment. Currently this classification relies mainly on histological assessment, but gene expression analysis bymicroarrays has shown great promise. Here we show that high accuracy, quantita...
ORGANISM(S): Homo sapiens (Human) 
2015-04-24 | PXD002098 | Pride
Classification Lymphoma Super silac Dlbcl 
ProteomicsHuman AML cell lines LC-MS/MS - Performance of Super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines
As a direct consequence of the high diversity of the aggressive blood cancer acute myeloid leukemia (AML), proteomic samples from patients are strongly heterogeneous, rendering their accurate relative quantification challenging. In the present study, we investigated the benefits of using a super-SI...
ORGANISM(S): Homo sapiens (Human) 
2014-07-15 | PXD000441 | Pride
Human Orbitrap velos pro Lc-ms Cell lines Super-silac Aml 
ProteomicsBiomarker discovery and subtype classification within Multiple Myeloma by Super-SILAC
Multiple Myeloma (MM) is the second most prevalent blood cancer (10%) after non-Hodgkin's lymphoma and represents approximately 1% of all cancers and 2% of all cancer deaths. MM is a complex disease characterized by numerous genetic alterations and recent mRNA profiling studies have attempted to sub...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD003138 | Pride
Silac Genome Correlation Lc-msms 
ProteomicsPROMIS-Quan: a novel proteomic method for plasma biomarker quantification
Unbiased proteomic analysis of plasma samples holds the promise to reveal clinically invaluable disease biomarkers. However the tremendous dynamic range of the plasma proteome has so far hampered the identification of such low abundant markers. To overcome this challenge we analyzed the plasma micro...
ORGANISM(S): Homo sapiens (Human) 
2015-01-28 | PXD001194 | Pride
Plasma Microparticles Super-silac Biomarkers 
ProteomicsSuper-SILAC analysis of human lung primary tumor-derived xenografts LC-MS/MS
Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is subdived into 2 major histological subtypes: adenocacinoma (ADC) and squamous cell carcinoma (SCC). Super-SILAC methodology was used to facilitate the quantitative comparisons of human primary tumor-derived xenograft proteom...
ORGANISM(S): Homo sapiens (Human) 
2014-01-28 | PXD000438 | Pride
Nsclc Proteomic profile Super-silac 
ProteomicsSuper-SILAC Allows Classification of Diffuse Large B-cell Lymphoma Subtypes by Their Protein Expression Profiles
Correct classification of cancer patients into subtypes is a prerequisite for acute diagnosis and effective treatment. Currently this classification relies mainly on histological assessment, but gene expression analysis bymicroarrays has shown great promise. Here we show that high accuracy, quantita...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-10 | MSV000079572 | MassIVE
ProteomicsSuper-SILAC reveals intricate crosstalk between lipopolysaccharide, phospholipid and fatty acid metabolism in Escherichia coli
The only membrane-anchored and essential ATP-dependent protease in Escherichia coli is FtsH. It controls the intracellular concentration of the deacetylase LpxC, which catalyses the first committed step in lipopolysaccharide biosynthesis. LpxC stability is strictly regulated in a growth rate-depende...
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD006195 | Pride
Lipopolysaccharide Lc-ms/ms Escherichia coli Ftsh Lpxc Proteolysis Super-silac Quantitative proteomics 
ProteomicsProteome alteration in Myeloma, MGUS to MM transition
We have measured the proteomic changes on ANBL6, IH1, INA6, U266, KJON, OH2, VOLIN, LR5, KARPAS, RAMOS cell lines and used it to build a super SILAC library in order to quantify proteomic changes from MGUG to MM stages of Myeloma with Elite orbitrap mass spetrometer.
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD006458 | Pride
Lr5 Oribitrap Volin Anbl6 Myeloma Oh2 U266 Silac Kjon Karpas Ih1 Super Ina6 Ramos 
ProteomicsSuper-SILAC analysis of human lung primary tumor-derived xenografts LC-MS/MS
Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is subdived into 2 major histological subtypes: adenocacinoma (ADC) and squamous cell carcinoma (SCC). Super-SILAC methodology was used to facilitate the quantitative comparisons of human primary tumor-derived xenograft proteom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-02 | MSV000079881 | MassIVE
ProteomicsSILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy
Post-hepatectomy liver failure (PHLF) remains a significant risk for patients undergoing partial hepatectomy (PHx). Reliable prognostic markers and treatments to enhance liver regeneration are lacking. Plasma nanoparticles, including lipoproteins, exosomes, and extracellular vesicles (EVs), can refl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059885 | Pride
Plasma extracellular vesicles Post-hepatectomy liver failure Proteomics 
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