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ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they a...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD025055 | Pride
Exocytosis Proteomics Snare proteins Immunological synapse Cytotoxic granules Single core granules Supramolecular attack particles Total internal reflection fluorescence microscopy Correlative light and electron microscopy Multi core granules 
UnknownSupramolecular attack particles are autonomous killing entities released from cytotoxic T cells.
Not available
S-EPMC7116847 | biostudies-literature
UnknownActivation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles.
Not available
S-EPMC11831147 | biostudies-literature
UnknownIdentification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.
Not available
S-EPMC8873490 | biostudies-literature
UnknownComparison of different methods for isolating CD8+ T lymphocyte‐derived extracellular vesicles and supramolecular attack particles
Not available
S-EPMC11080737 | biostudies-literature
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