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ProteomicsMethyltransferase-like 3 (METTL3) regulates exocytosis
RNA modification pathways are often mis-regulated in various typers of cancer, with N6-methyladenosine (m6A) playing a pivotal role in cancer progression and metastasis. Methyltransferase-like 3 (METTL3), a core component of the m6A methyltransferase complex, functions not only as an m6A writer but ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD066045 | Pride
Exoc7 Breast cancer Rna modification Vesicle trafficking Exocyst N6-methyladenosine Mettl3 
UnknownThe SNAP-25 linker as an adaptation toward fast exocytosis.
Not available
S-EPMC2526689 | biostudies-literature
GenomicsLiver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis
Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis
PRJNA771352 | ENA
GenomicsOCaR1, a gatekeeper of lysosomal and granular Ca2+ release and regulated exocytosis
OCaR1, a gatekeeper of lysosomal and granular Ca2+ release and regulated exocytosis
PRJNA434189 | ENA
ProteomicsCharacterization of a novel membrane complex required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila
In the ciliate Tetrahymena thermophila, lysosome-related organelles called mucocysts accumulate at the cell periphery where they secrete their contents in response to extracellular events, a phenomenon termed regulated exocytosis. A forward genetic approach uncovered MDL1 (Mucocyst Discharge with a ...
ORGANISM(S): Tetrahymena thermophila CU428 
2022-04-06 | PXD028372 | Pride
Exocytosis Mucocysts Ciliate Tetrahymena Lysosome Mdl1 
UnknownPotential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells.
Not available
S-EPMC7243297 | biostudies-literature
UnknownModulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.
Not available
S-EPMC4413049 | biostudies-literature
GenomicsGalns-deficiency enhances lysosomal exocytosis and alters cartilage development in zebrafish
Galns-deficiency enhances lysosomal exocytosis and alters cartilage development in zebrafish
PRJNA1282735 | ENA
ProteomicsMYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation
Many cancer cells exhibit increased amounts of paucimannose glycans, which are truncated N-glycan structures rarely found in mammals. Paucimannosidic proteins are proposedly generated within lysosomes and exposed on the cell surface through a yet uncertain mechanism. In this study, we assured that p...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD051592 | Pride
Paucimannose Glycoproteomics Lysosome Hela Hek293 Thp1 Myo18b 
TranscriptomicsOCaR1, a gatekeeper of lysosomal and granular Ca2+ release and regulated exocytosis
During exocytosis, a Ca2+ increase arises in close vicinity of secretory granules which is strictly prevented in resting cells. Granular Ca2+ homeostasis and its role in granular exocytosis are not well understood.
ORGANISM(S): Mus musculus 
2018-08-14 | GSE110646 | GEO
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