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ProteomicsGlycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain
Alterations of protein abundance and post-translational modifications in patients with Alzheimer’s disease (AD), such as glycosylation, phosphorylation, and ubiquitination, and their roles in disease progression and treatment outcome are areas of intense study. Little is known, however, about...
ORGANISM(S): Homo sapiens (Human) 
2022-10-31 | PXD032219 | Pride
Glycoproteins Mass spectrometry Glycoproteomics Alzheimer's 
ProteomicsMucin-type O-glycans enrich in white matter tracts
Protein O-glycosylation, the enzymatic attachment of carbohydrates to serine/threonine/tyrosine residues, is a large group of essential post-translational modifications involved in brain development and disease. However, studies of the most abundant O-glycan class in the mammalian brain, termed muci...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-10 | PXD041631 | Pride
Glycoproteomics  pna  o-glycans 
ProteomicsLarge-scale and Site-specific Mapping of Intact O-glycans on Glycopeptides with IMPa
We employed the newly available IMPa O-glycoprotease from Pseudomonas aeruginosa for O-glycoproteomics analysis of cultured cells and tissues. The glycopeptides were extracted, purified, and conjugated to a solid support before an enzymatic cleavage by IMPa. O-glycopeptides were analyzed by EThcD, w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-08-28 | PXD037415 | Pride
O-glycoproteomics  impa  vva  rax  tn antigen 
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