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TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [cell culture]
Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed a...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66758 | biostudies-arrayexpress
TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [patients]
Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed a...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66759 | biostudies-arrayexpress
TranscriptomicsTTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
Adenocarcinoma is the most common histologic subtype of lung cancer, which is the leading cause of cancer death. We and others previously identified TTF-1, a lineage-specific transcription factor required for branching morphogenesis and physiological lung functions, as a lineage-survival oncogene in...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-25830 | biostudies-arrayexpress
UnknownTTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-25830 | biostudies-other
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features
Accumulation of genetic and epigenetic changes alters regulation of a web of interconnected genes including miRNAs, which confer hallmark capabilities and characteristic cancer features. In this study, the miRNA and mRNA expression profiles of 126 non-small cell lung cancer specimens were analyzed, ...
ORGANISM(S): Homo sapiens 
2014-06-19 | E-GEOD-51853 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features
Accumulation of genetic and epigenetic changes alters regulation of a web of interconnected genes including miRNAs, which confer hallmark capabilities and characteristic cancer features. In this study, the miRNA and mRNA expression profiles of 126 non-small cell lung cancer specimens were analyzed, ...
ORGANISM(S): Homo sapiens 
2014-06-19 | E-GEOD-51852 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features
Accumulation of genetic and epigenetic changes alters regulation of a web of interconnected genes including miRNAs, which confer hallmark capabilities and characteristic cancer features. In this study, the miRNA and mRNA expression profiles of 126 non-small cell lung cancer specimens were analyzed, ...
ORGANISM(S): Homo sapiens 
2014-06-19 | E-GEOD-51854 | biostudies-arrayexpress
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