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TranscriptomicsIdentification of genes that are regulated by TAK1 in human cutaneous T cell lymphoma HuT-102 cells
We previously reported that human T cell lymphotropic virus 1 (HTLV-1) Tax oncoprotein constitutively activates TAK1. Here, we established Tax-positive HuT-102 cells stably downregulated TAK1 expression by short-hairpin RNA (HuT-shTAK1 cells), and investigated the physiological function of TAK1. Mic...
ORGANISM(S): Homo sapiens 
2009-08-18 | E-GEOD-16219 | biostudies-arrayexpress
UnknownPresence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1-42) in amino acid sequence independent manner.
Not available
S-EPMC7378830 | biostudies-literature
UnknownA cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly.
Not available
S-EPMC9157467 | biostudies-literature
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
TranscriptomicsGenome-wide translational analysis of the effect of acute endurance exercise on mouse gastrocnemius
Purpose: The aim of this study is to investigate the translational regulation of skeletal muscle during acute endurance exercise. Methods: We used mRNA-Seq and ribosome profiling to examine transcriptional and translational regulation, respectively. Result: There were clear distinctions between the ...
ORGANISM(S): Mus musculus 
2016-02-16 | E-GEOD-69699 | biostudies-arrayexpress
ProteomicsTMT quantification of insoluble fractions in SH-SY5Y
To identify the misfolded proteins which can be rescued by slowing down translation speed of ribosomes by a very low concentration of cycloheximide.
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD030259 | Pride
Misfolding 
UnknownCrystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.
Not available
S-EPMC4353363 | biostudies-literature
TranscriptomicsEffect of Kurozu on hippocampal gene expression profiles in SAMP8
Kurozu is a traditional Japanese rice vinegar. During fermentation and aging of the Kurozu liquid in an earthenware jar over 1 year, solid residue called Kurozu Moromi is produced. In the present study, we evaluated whether concentrated Kurozu or Kurozu Moromi could ameliorate cognitive dysfunction ...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-70514 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in thyrocytes between wildtype and thyroid-specific IFNg transgenic mice
Hürthle cells are found in thyroid tumors and autoimmunity, and have a unique appearance characterized by swollen eosinophilic cytoplasm filled with mitochondria and hyperchromatic nucleus. The pathogenesis of Hürthle cells remains unknown. We have generated transgenic mice expressing IFNg specifica...
ORGANISM(S): Mus musculus 
2009-07-01 | E-GEOD-15114 | biostudies-arrayexpress
UnknownDistinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cells.
Not available
S-EPMC10617393 | biostudies-literature
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