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UnknownSAR by kinetics for drug discovery in protein misfolding diseases.
Not available
S-EPMC6187117 | biostudies-literature
GenomicsNascent chain misfolding slows translation and stimulates co-translational mRNA decay
Nascent chain misfolding slows translation and stimulates co-translational mRNA decay
PRJNA1227984 | ENA
ProteomicsExpression dynamics in mammalian cells responding to protein misfolding stress
The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and p...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002039 | Pride
Human Lc-msms Protein misfolding stress Hela 
UnknownDestabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core.
Not available
S-EPMC12746452 | biostudies-literature
GenomicsAssembly Factors and snoRNAs Manage Programmable RNA Folding and Misfolding to Support Growth in Stationary Phase
Assembly Factors and snoRNAs Manage Programmable RNA Folding and Misfolding to Support Growth in Stationary Phase
PRJNA1492118 | ENA
ProteomicsNanobodies as therapies for loss-of-function misfolding diseases
Misfolding loss-of-function diseases are a huge burden for people and states. Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by mutations in the alanine:glyoxylate aminotransferase 1 (AGT) enzyme. The underlying molecular mechanisms causing PH1 are associated with protein misfo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD060227 | Pride
Hyperoxaluria  protein misfolding   inborn error of metabolism  therapeutics  nanobodies 
TranscriptomicsExpression data for inbred mouse brains
Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic backgro...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38205 | biostudies-arrayexpress
GenomicsER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)
ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)
PRJNA867561 | ENA
GenomicsER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)
ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)
PRJNA866080 | ENA
GenomicsProtein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
PRJNA854161 | ENA
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