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GenomicsHuman embryonic stem cells HELP-tagging cytosine methylation data (Albert Einstein College of Medicine)
Background: To perform epigenome-wide association studies in human disease, assays need to be comprehensive and quantitative while remaining cost-effective. We explored how the strengths of prior tag-based cytosine methylation assays based on massively-parallel sequencing can be maximised analytica...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19937 | biostudies-arrayexpress
GenomicsPeripheral blood mononuclear cells HELP-tagging cytosine methylation data (Albert Einstein College of Medicine)
Obesity-associated asthma is recognized as a distinct entity with non-atopic T-helper 1 polarized systemic inflammation. DNA methylation is linked with T helper cell maturation and is associated with inflammatory patterns in asthma and obesity. However, it is unknown whether pathologic dysregulation...
ORGANISM(S): Homo sapiens 
2014-04-14 | E-GEOD-43705 | biostudies-arrayexpress
GenomicsHEK 293T cells HELP-tagging cytosine methylation data treated with 5-aza-2-deoxycytidine
DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test how 5-aza-2...
ORGANISM(S): Homo sapiens 
2015-02-13 | E-GEOD-62592 | biostudies-arrayexpress
GenomicsGenome-wide maps of RNAPII Ser5(P) in HEK 293T cells after treatment with 5-aza-CdR
DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test how 5-aza-2...
ORGANISM(S): Homo sapiens 
2015-02-13 | E-GEOD-62695 | biostudies-arrayexpress
TranscriptomicsHEK 293T cells RNA-seq data treated with 5-aza-2-deoxycytidine
DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test how 5-aza-2...
ORGANISM(S): Homo sapiens 
2015-02-13 | E-GEOD-62591 | biostudies-arrayexpress
TranscriptomicsEpigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
The increase in atopic diseases has occurred in such a short period of time that it becomes difficult to be attributed only to genetic factors, which usually need more prolonged time periods to manifest. In this setting during the last decade, the science of epigenetics has increasingly developed of...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-26080 | biostudies-arrayexpress
GenomicsLoss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
Multiple endocrine neoplasia type 1 (MEN1) syndrome is the result of mutations in the MEN1 gene and results in tumor formation via mechanisms that are not well understood. Using a novel genome-wide methylation analysis, we studied tissues from patients with MEN1-parathyroid tumors, tissues from Men1...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-64412 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation in paired lung tumor/non-tumor samples using the HELP assay
In lung cancer, hypermethylation of specific gene promoters has been found during the progressive carcinogenesis. The identification of common methylation events will aid in the understanding of molecular events during neoplastic transformation and help develop biomarkers for cancer with high predic...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-GEOD-35520 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Chronic kidney disease
Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine meth...
ORGANISM(S): Homo sapiens 
2013-07-18 | E-GEOD-48944 | biostudies-arrayexpress
TranscriptomicsLATE-REPLICATING HETEROCHROMATIN IS CHARACTERISED BY DECREASED CYTOSINE METHYLATION IN THE HUMAN GENOME (expression)
Heterochromatin is believed to be associated with increased levels of cytosine methylation. With the recent availability of genome-wide, high-resolution molecular data reflecting cytosine methylation or heterochromatic organization, such relationships can be explored systematically. As a well-defi...
ORGANISM(S): Homo sapiens 
2011-08-05 | E-GEOD-27518 | biostudies-arrayexpress
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