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UnknownReduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
Not available
S-EPMC9649636 | biostudies-literature
TranscriptomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75177 | biostudies-arrayexpress
GenomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [ChIP-Seq]
Nrf2(A502Y) mutant macrophages Nrf2(AY/AY) macrophages were more susceptible to toxicity of xenobiotics. To confirm preferences of binding sequences of Nrf2 and Nrf2A502Y in vivo, we performed ChIP-Seq analyses using an anti-Nrf2 antibody on the DEM-treated peritoneal macrophages derived from Nrf2+/...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75175 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene
To examine the NRF2 activity in anaplastic glioma with mutated IDH1/2, we conducted the microarray analysis to measure the expression levels of representative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2.
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-52942 | biostudies-arrayexpress
TranscriptomicsNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upr...
ORGANISM(S): Mus musculus 
2016-05-12 | E-GEOD-71263 | biostudies-arrayexpress
UnknownCryo-EM SPA dataset of arginine oxidase from Pseudomonas sp. TRU 7192
Not available
EMPIAR-13426 | biostudies-other
TranscriptomicsGene expression profiles of serous ovarian cancer samples
To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene expression profiles from forty-three ovarian cancer tissues comprising eight early stage and thirty-five advanced stage tissues were performed using oligonucleotide microarrays of 18,716 genes. By non-negative matrix fac...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-12470 | biostudies-arrayexpress
TranscriptomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [RNA-Seq]
Nrf2(A502Y) mutant failed to recognize cis-element required for induction of Nrf2 target genes.To examine whether Nrf2(A502Y) supports expression of a distinct gene set from that supported by Nrf2, RNA-Seq analysis was performed. We compared gene expression profiles in peritoneal macrophages from Nr...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75176 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of chicken and Japanese quail
Since Japanese quail and chicken belong to the same order Galliforms, DNA sequence of both species are highly conserved and proved to be applicable for various analyses each other. Quail are commonly used to address physiological questions for reasons of economy. To test whether chicken microarrays ...
ORGANISM(S): Coturnix japonica 
2008-11-06 | E-GEOD-8016 | biostudies-arrayexpress
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