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TranscriptomicsAcute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome [methylation]
Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed ...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-54840 | biostudies-arrayexpress
TranscriptomicsMethylation data from presentation and relapsed medulloblastoma tumour samples
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive d...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-62618 | biostudies-arrayexpress
UnknownA Graduate Medical Orientation Intervention Focused on Local Health Inequities
Not available
S-EPMC10449351 | biostudies-literature
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsEpigenetic signatures of alcohol abuse and hepatitis infection during hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. Altered DNA methylation landscapes are ubiquitous features of cancer. Interpretation of epigenetic aberrations in HCC is confounded by effects of multiple etiologic drivers and underlying cirrhosis in most cas...
ORGANISM(S): Homo sapiens 
2014-09-16 | E-GEOD-60753 | biostudies-arrayexpress
TranscriptomicsCombined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-62626 | biostudies-arrayexpress
TranscriptomicsDNA methylation in Early Onset Preeclamptic placentas
We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to e...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-44667 | biostudies-arrayexpress
UnknownCyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis.
Not available
S-EPMC7849715 | biostudies-literature
UnknownAssessment of a Tele-education System to Enhance Retinopathy of Prematurity Training by International Ophthalmologists-in-Training in Mexico.
Not available
S-EPMC7895299 | biostudies-literature
UnknownIdentification of genes required for eye development by high-throughput screening of mouse knockouts.
Not available
S-EPMC6303268 | biostudies-literature
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