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ProteomicsCardiac phosphoproteome of the mouse model of propionic acidemia
Ventricular tissue of 8 week female PA mice (https://pubmed.ncbi.nlm.nih.gov/23648696/) and their female wild-type littermates were processed for phosphoproteomics
ORGANISM(S): Mus musculus (Mouse) 
2023-09-28 | PXD043384 | Pride
Cardiac Propionic acidemia 
ProteomicsNHE1 phosphorylation analysis in cardiomyocytes in normoxic and anoxic conditions
Na+/H+ exchanger 1 (NHE1; SLC9A1) is a transport protein responsible for pH regulation in various types of cells. In cardiac myocytes, NHE1 generates the largest transmembrane acid-extrusion flux and is therefore the most significant controller of the intracellular acid/base milieu. The protein itse...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-26 | PXD022853 | Pride
Phosphorylation Na+/h+ exchanger 1 Anoxic 
ProteomicsDisrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Propionate is a common three-carbon intermediate produced from the breakdown of propiogenic substrates, such as branched-chain amino acids and odd-numbered fatty acids, and by gut bacteria. Propionate can chemically modify proteins, and if this involves histones, it may underpin a disease-relevant l...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-09-29 | PXD043513 | Pride
Heart failure Histone Contraction Epigenetics Propionic acidemia 
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