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ProteomicsProteome analysis of the retina from RhoQ344X/+ mouse
Retinal proteomes from wild-type and RhoQ344X mutant mice at postnatal day 35 were analyzed by label-free quantitative proteomics to understand proteomic change caused by the rhodopsin mutation.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-08 | MSV000093339 | MassIVE
TranscriptomicsNovel strategies to enforce an epithelial phenotype in mesenchymal cells
E-cadherin downregulation in cancer cells is associated with epithelial-to-mesenchymal transition (EMT) and metastatic prowess, but the underlying mechanisms are incompletely characterized. In this study, we probed E-cadherin expression at the plasma membrane as a functional assay to identify genes ...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-57660 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine reveals fasting induces a biphasic adaptive metabolic response
Background; The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results; In...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-8019 | biostudies-arrayexpress
ProteomicsProteomic analysis of healthy and hyperglycemic murine fetal kidneys
Alteration of kidney morphogenesis in diabetic pregnancies is poorly described, especially changes in the extracellular matrix (ECM) and glomerular basement membrane (GBM during glomerulogenesis. Addressing the ECM proteome, or matrisome, in the mouse fetal kidney in a healthy and diabetic environme...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-13 | PXD025874 | Pride
Mass spectrometry Basement membrane Enrichment Kidney Extracellular matrix Diabetes 
TranscriptomicsGene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38218 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in mice infected with distinct Toxoplasma gondii strains
Transcriptome analysis of peritoneal lavage of mice infected with T. gondii Toxoplasma gondii is the causative agent of toxoplasmosis in human and animals. In mouse model, T. gondii strains can be divided into three groups, including the virulent, intermediately virulent and non-virulent. The clonal...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-34416 | biostudies-arrayexpress
TranscriptomicsGraphene Oxide Substrate Promotes Neurotrophic Factor Secretion and Survival of Human Schwann-Like Adipose Mesenchymal Stromal Cells - RNAseq
Mesenchymal stromal cells from adipose tissue (AD-MSCs) exhibit favourable clinical traits for autologous transplantation and can develop a ‘Schwann-like’ phenotype (sAD-MSCs) to improve peripheral nerve regeneration, where severe injuries yield insufficient recovery. However, sAD-MSCs regress witho...
ORGANISM(S): Homo sapiens 
2021-03-08 | E-MTAB-10078 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse intestinal adenoma organoids treated with pre- and post-exercise human serum
This experiment investigated transcriptomic responses of mouse intestinal adenoma organoids to circulating factors induced by acute exercise. Intestinal adenoma organoids derived from an Lgr5-creER;Apcfl/fl mouse model were cultured with 1% human serum collected immediately before or after a maximal...
ORGANISM(S): Mus musculus 
2026-10-10 | E-MTAB-17712 | biostudies-arrayexpress
TranscriptomicsGene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expansion a...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-38219 | biostudies-arrayexpress
TranscriptomicsAnalysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access
Currently, the mechanisms behind the anti-aging effects of exercise are not understood. The presented study conducted a microarray on hippocampal samples from adult (3.5 month-old) and aged (18 month-old) male BALB/c mice that were individually housed with or without running wheels for 8 weeks. Resu...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-29075 | biostudies-arrayexpress
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