Sort   by:  
 Page size 
ProteomicsQuantification of Alpha synuclein in erythrocytes
Idiopathic Parkinson’s disease (iPD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). Mutations in the SCNA gene, which encodes the protein alpha synuclein (α-syn), are associated with familial forms of Parkinson's disease (PD). Additionally, Lewy bodies (LBs) rich...
ORGANISM(S): Homo Sapiens 
PXD058953 | panorama
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
TranscriptomicsExpression data from serum-stimulated NIH 3T3 cells stably expressing control (pLKO.1) vector or shRNAs targeting Net or Sap-1
Although much is known about focal adhesion signaling induced by cell adhesion, how adhesion directs changes in transcription to control cell behavior is far less understood. Here we describe a novel mechanism by which changes in adhesion switch the activities of the mitogen-activated protein kinas...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-26640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast grown in a three-factor design to study the relationship between specific growth rate and genome-wide gene expression
A three-factor design was applied to study the relationship between specific growth rate and genome-wide gene expression in 36 steady-state chemostat cultures of Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2009-01-15 | E-MTAB-78 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from wild type and IRAK-4 kinase dead animals stimulated with IL-1b for different durations to identify IRAK-4 kinase-dependent IL-1b response genes.
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Though regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. In order to investigate the role ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6789 | biostudies-arrayexpress
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
TranscriptomicsTranscription profiling of mouse immature pDC and pDC activated with CpG 1826 and influenza virus PR8
CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC; We used microarrays to detail the global progr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7831 | biostudies-arrayexpress
TranscriptomicsFoam cell specific LXRM-NM-1 ligand
OBJECTIVE: The liver X receptor M-NM-1 (LXRM-NM-1) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an interesting target for mechanistic study and treatment of atherosclerosis. METHODS AND RESULTS: We optimized a promising...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-39079 | biostudies-arrayexpress
TranscriptomicsTransformation of the intestinal epithelium by the MSI2 RNA binding protein
The MSI2 RNA binding protein has recently emerged as a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Here we demonstrate that MSI2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinom...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64388 | biostudies-arrayexpress
Sort   by:  
 Page size