Synaptic adhesion

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Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
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Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, Institute of Brain Functional Genomics, School of Life Science and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, China (3)
Biochemistry III, Department of Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany (1)
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. (1)
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Professor and Vivian L. Smith Endowed Chair in Neuroscience Department of Neuroscience. Baylor College of Medicine Houston, Texas United States (1)
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Shenyang Medical College; The Second Affiliated Hospital of Shenyang Medical College. The Veterans General Hospital of Liaoning Province (1)
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Synapse Development and Plasticity Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Quebec, H2W 1R7, Canada Integrated Program in Neuroscience, McGill University, Montreal, Quebec, H3A 2B2, Canada Department of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada Division of Experimental Medicine, McGill University, Montreal, Quebec, H3A 0G4, Canada (1)
Synapse Development and Plasticity research unit Institut de recherches cliniques de Montréal (IRCM) 110, avenue des Pins Ouest – Laboratory 5340 Montréal (Quebec) Canada H2W 1R7 (1)
The Rockefeller University (1)
The Second Affiliated Hospital of Shenyang Medical College. The Veterans General Hospital of Liaoning Province (1)
UNC Neuroscience Center, Cell Biology and Physiology, The University of North Carolina at Chapel Hill (1)

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Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion

Genome-wide association studies have convincingly implicated several novel genes in susceptibility to schizophrenia and bipolar disorder. The first genome-wide significant association with the broad phenotype of psychosis was with a polymorphism in the ZNF804A gene. However, the biological function(...

ORGANISM(S): Homo sapiens

2011-11-16 | E-GEOD-28725 | biostudies-arrayexpress

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.

Not available

S-EPMC5010778 | biostudies-literature

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies we performed proteomics in rat primary neurons to ...

ORGANISM(S): Rattus norvegicus (Rat)

2021-06-28 | PXD026289 | Pride

N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion.

Not available

S-EPMC2966101 | biostudies-literature

LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate.

Not available

S-EPMC5645493 | biostudies-literature

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

Not available

S-EPMC4974644 | biostudies-literature

Membrane trafficking of synaptic adhesion molecules.

Not available

S-EPMC12559978 | biostudies-literature

Synaptic activity-regulated gene expression_embryonic day 16

Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null ...

ORGANISM(S): Mus musculus

2006-07-31 | E-GEOD-3638 | biostudies-arrayexpress

Identification of palmitoyl protein thioesterase 1 substrates defines roles for synaptic depalmitoylation

We report here the identification of substrates of the depalmitoylating enzyme PPT1 by quantitative mass spectrometry. We utilized a stringent two-step Acyl Resin-Assisted Capture (Acyl RAC) screen in which increased palmitoylation in vivo in PPT1 knockout is the first selection criteria for substra...

ORGANISM(S): Mus musculus (Mouse)

2022-05-19 | PXD017270 | Pride

Synapse Synaptic cleft Synaptic vesicle endocytosis Neuronal ceroid lipofuscinoisis Synaptic adhesion molecules Ampa receptor Neurodegeneration Palmitoylation Palmitoyl protein thioesterase 1

N-glycoproteomics of brain synapses and synaptic vesicles

At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs. Despite this key role for N-glycosylation, the molecular compositi...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2023-03-18 | MSV000091507 | MassIVE

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