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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
ProteomicsMapping the proteome of the synaptic cleft through peroxidase-based reporter protein SynCAM1-HRP
Synapses are the brain’s functional units connecting neurons into circuits that underlie memory and behavior. These specialized neuronal junctions are heterogenic in function and molecular composition, reflecting diverse health and disease states. Progress over the past years has shown that trans-sy...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-04 | PXD011312 | Pride
Lc ms/ms Synaptomics Synaptic cleft Synapse composition Syncam1 Proximity labeling Proteomics 
UnknownMapping the Proteome of the Synaptic Cleft through Proximity Labeling Reveals New Cleft Proteins.
Not available
S-EPMC6313906 | biostudies-literature
UnknownNeurexins - versatile molecular platforms in the synaptic cleft.
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S-EPMC6592730 | biostudies-literature
UnknownPresynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.
Not available
S-EPMC2000325 | biostudies-literature
UnknownPostsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft.
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S-EPMC10423045 | biostudies-literature
UnknownTopographic Mapping of the Synaptic Cleft into Adhesive Nanodomains.
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S-EPMC4687029 | biostudies-literature
UnknownComputational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.
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S-EPMC8715252 | biostudies-literature
UnknownSynaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time.
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S-EPMC11993924 | biostudies-literature
UnknownExtracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft.
Not available
S-EPMC4028192 | biostudies-literature
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