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MetabolomicsGut Microbiota–Derived Ergothioneine Alleviates Antipsychotic-Induced Synaptic and Cognitive Impairments

Background: Chronic use of antipsychotic drugs is associated with neuronal damage and cognitive impairment, potentially mediated by alterations in gut microbiota metabolites, although the specific metabolite involved remains unknown.

Objective: To identify the key metabolite responsible for...

2026-04-08 | MTBLS12751 | MetaboLights
GenomicsDeficiency Disrupts Photoreceptor Viability and Synaptic Integrity in a Choroideremia Mouse Model
Deficiency Disrupts Photoreceptor Viability and Synaptic Integrity in a Choroideremia Mouse Model
PRJNA1328629 | ENA
GenomicsNeuronal integrity, not activity, drives synaptic material clearance by microglia after CNS injury
Neuronal integrity, not activity, drives synaptic material clearance by microglia after CNS injury
PRJNA420938 | ENA
ProteomicsSynapse integrity and function: dependence on protein synthesis and identification of potential failure points
Synaptic integrity and function depend on myriad proteins - labile molecules with finite lifetimes that need to be continually replaced with freshly synthesized copies. Here we describe experiments designed to expose synaptic (and neuronal) properties and functions that are particularly sensitive to...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-27 | PXD037859 | Pride
Silac Protein synthesis Synaptic integrity 
GenomicsElovanoid neuroprotection targets cell transcriptomics and proteomics to sustain synaptic integrity ater brain injury
Elovanoid neuroprotection targets cell transcriptomics and proteomics to sustain synaptic integrity ater brain injury
PRJNA1435160 | ENA
TranscriptomicsAstrocyte-encoded positional cues maintain sensorimotor circuit integrity
Astrocytes, the most abundant cells in the central nervous system, promote synapse formation and help refine neural connectivity. Although they are allocated to spatially distinct regional domains during development, it is unknown whether region-restricted astrocytes are functionally heterogeneous. ...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-55054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Alzheimers disease patients to identify genes regulating synaptic function and neuroplasticity in incipient AD
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12685 | biostudies-arrayexpress
UnknownEssential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy.
Not available
S-EPMC10691399 | biostudies-literature
UnknownMitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance.
Not available
S-EPMC7507095 | biostudies-literature
TranscriptomicsDeficiency Disrupts Photoreceptor Viability and Synaptic Integrity in a Choroideremia Mouse Model
Choroideremia, an X-linked retinal dystrophy causing progressive vision loss, arises from deficient Rab escort protein-1 (REP1), critical for the prenylation of Rab proteins. The precise mechanisms linking REP1 dysfunction to retinal degeneration remain unclear. Here, we generated conditional REP1 k...
ORGANISM(S): Mus musculus 
2026-01-12 | GSE308042 | GEO
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