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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (miRNA array)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43943 | biostudies-arrayexpress
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (RT-PCR)
It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein synthesis. A growing amount of evidence suggests that the microRNA (miRNA) pathway plays an important role in coordinating these processes. Despi...
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43944 | biostudies-arrayexpress
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
TranscriptomicsThe miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-02-01 | E-GEOD-43945 | biostudies-arrayexpress
TranscriptomicsFiber and NMJ / synaptic gene expression comparisons in rat extraocular muscle (EOM) and tibialis anterior (TA) muscle.
Purpose: To examine and characterize the expression profile of genes expressed at the neuromuscular junctions (NMJs) of extraocular muscles (EOMs) in comparison to the NMJs of tibialis anterior muscle (TA). Methods: Adult rat rectus EOMs and TAs were dissected, flash-frozen, serially sectioned and ...
ORGANISM(S): Rattus norvegicus 
2010-04-28 | E-GEOD-15737 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
ProteomicsProteomic analysis of brain region and gender-specific synaptic protein expression in the adult mouse brain
In a wide range of synaptopathies a sex/gender bias in prevalence and clinical course has been reported. Therefore, analysis of the synaptic proteinaceous inventory in different brain regions in males and females is very desirable in understanding the molecular basis of brain function and the etiolo...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015610 | Pride
Sex/gender bias Prefrontal cortex Hippocampus Cerebellum Striatum Synaptic junction Label-free quantification Data-independent acquisition 
TranscriptomicsSynaptic activity-regulated gene expression_embryonic day 16
Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null ...
ORGANISM(S): Mus musculus 
2006-07-31 | E-GEOD-3638 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis reveals molecular adaptations in the hippocampal synaptic active zone of chronic mild stress-unsusceptible rats
Background: While stressful events are recognized as an important cause of major depressive disorder (MDD), some individuals exposed to life stressors maintain normal psychological functioning. Although the molecular mechanism(s) underlying this phenomenon remain unclear, abnormal transmission and p...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-11-05 | PXD002540 | Pride
Rat hippocampus Triple tof 5600 Itraq Lc-ms/ms 
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