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MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
ProteomicsVAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity
Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are energy consumption hotspots susceptible to dysfunction when their energy supplies are perturbed. Mitochondria are stabilized near synapses via the cytoskeleton and provide the local energy required for synaptic...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-11-27 | PXD047226 | Pride
Proximity labeling Mitochondria Synaptic plasticity 
ModelsLi2012 Calcium mediated synaptic plasticity
Li2012 Calcium mediated synaptic plasticity This model is an extension of  BIOMD0000000183. This model is described in the article: Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. Li L, Stefan MI, Le N...
2024-09-02 | BIOMD0000000628 | BioModels
ProteomicsPathological deficit of Cystatin B impairs synaptic plasticity in EPM1 human cerebral organoids
Cystatin B (CSTB) is a small protease inhibitor involved in cell proliferation and migration, and composition of extracellular matrix during brain development. Loss-of-function mutations in the gene encoding CSTB cause progressive myoclonic epilepsy 1 (EPM1). We previously demonstrated that CSTB is ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041125 | Pride
Epm1  cystatin b  synaptic plasticity 
UnknownSUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity.
Not available
S-EPMC3435142 | biostudies-literature
ProteomicsFocal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory
Experience-dependent learning depends on synaptic plasticity. Recent findings show that effective integration of novel salient information requires coordinated processes of homo- and hetero- synaptic plasticity onto neighboring dendritic branches. In this work, we hypothesized that activity-dependen...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-10 | PXD047129 | Pride
Synaptic plasticity Cs56 clusters Extracellular matrix Versican. Learning and memory 
ModelsNakano2010_Synaptic_Plasticity
This is an SBML version of the model described in: A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. Nakano T, Doi T, Yoshimoto J, Doya K. PLoS Comput Biol. 2010 Feb 12;6(2):e1000670. PMID: 20169176 ; DOI: 10.1371/journal.pcb...
2005-01-01 | MODEL1101170000 | BioModels
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