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ProteomicsA Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue Lysate and Synaptosome Preparations from Frozen Post-Mortem Brain Samples
Recent advancements in neuroproteomics have enabled detailed analysis of protein expression and function in the human brain, improving our understanding of the relationship between genetics, cell biology of neurological and psychiatric disorders and their clinical diagnosis. Synaptic dysfunction oft...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD076278 | Pride
ProteomicsDevelopmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function
Large-scale genomic studies of schizophrenia implicate genes involved in the epigenetic regulation of transcription by histone methylation and genes encoding components of the synapse. However, the interactions between these pathways in conferring risk to psychiatric illness are unknown. Loss-of-fun...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-26 | PXD032742 | Pride
Schizophrenia Setd1a Development Neuronal Synaptosome 
ProteomicsSynaptosome analysis Vps35l conditional knock-out mouse
Here, using synaptosome analysis of Vps35l-cKOSynapsin1, we provide a data-rich resource that reveals novel molecular insights into how VPS35L work in synapse.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD064880 | Pride
Synapsin1 Vps35l Synaptosome Tmt label Lc-ms/ms 
Genomics
Mouse synaptosome
PRJNA361005 | ENA
GenomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Transcriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
PRJNA686431 | ENA
Proteomicscross-linking mass spectrometry of synaptosome
Cross-linking mass spectrometry data of synaptosome and microsome fractions of mouse cerebellum and hippocampus.
ORGANISM(S): Mus musculus (Mouse) 
2020-12-03 | PXD010317 | Pride
Synaptosome Microsome Cross-linking mass spectrometry 
ProteomicsSynaptosomal proteome from schizophrenia patients
Proteomic characterization of the synaptosome fraction of the orbitofrontal cortex using label-free and iTRAQ labeling strategies.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-30 | MSV000086389 | MassIVE
TranscriptomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Shank3 protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies including autism spectrum disorders. Although Shank3 function as a postsynaptic scaffold is well established, other potential mechanisms how Shank3 broadly modul...
ORGANISM(S): Mus musculus 
2023-12-18 | GSE163528 | GEO
GenomicsSynaptosome Sorting Using Reversible Fixative—A Versatile Approach for Synaptic Transcriptome Sequencing (SynSURF-Seq)
Synaptosome Sorting Using Reversible Fixative—A Versatile Approach for Synaptic Transcriptome Sequencing (SynSURF-Seq)
PRJNA1405760 | ENA
ProteomicsSynaptosomal proteome from schizophrenia patients
Proteomic characterization of the synaptosome fraction of the orbitofrontal cortex using label-free and iTRAQ labeling strategies.
ORGANISM(S): Homo sapiens (Human) 
2017-09-29 | PXD006798 | Pride
Schizophrenia Synaptosome Quantitative proteomics 
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