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MetabolomicsMetabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

INTRODUCTION: Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aime...

2025-05-27 | MTBLS9665 | MetaboLights
MetabolomicsMetabolic Profiling of Synovial Fluid in Human Temporomandibular Joint Osteoarthritis

INTRODUCTION: Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aime...

2025-05-27 | MTBLS9662 | MetaboLights
MetabolomicsSynovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies
Osteoarthritis (OA), osteochondrosis (OC), and synovial sepsis in horses cause loss of function and pain. Reliable biomarkers are required to achieve accurate and rapid diagnosis, with synovial fluid (SF) holding a unique source of biochemical information. Nuclear magnetic resonance (NMR) spectrosco...
2018-07-20 | MTBLS543 | MetaboLights
MetabolomicsNon-targeted metabolomics analysis of synovial fluid from TMD patients
This study performed non-targeted metabolomics detection on 62 human joint cavity lavage fluid samples using UHPLC-QE-MS. Metabolites were extracted with methanol:acetonitrile (1:1), separated on a Waters ACQUITY UPLC BEH Amide column, and detected by Orbitrap Exploris 120 mass spectrometer in both ...
2026-09-23 | MTBLS14238 | MetaboLights
MetabolomicsMetabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging

BACKGROUND: Palmar osteochondral disease (POD) is a common cause of lameness in competition horses. Magnetic resonance imaging (MRI) is the most sensitive diagnostic modality currently available, however it may not be financially or logistically practical for routine screening o...

2021-11-12 | MTBLS1435 | MetaboLights
Metabolomics1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients
Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used pr...
2020-11-10 | MTBLS1894 | MetaboLights
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
TranscriptomicsSingle cell RNAseq of ankylosing spondylitis lymphocytes from peripheral blood and synovial fluid
Single-cell transcriptome of >55,000 cells multiplexed into 4 channels obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis,.
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10948 | biostudies-arrayexpress
TranscriptomicsSmall non-coding RNAs in early equine osteoarthritis synovial fluid
Small RNA isolated from synovial fluid of the metacarpophalangeal joints of horses. Horses either had minimal signs of osteoarthritis based on macroscopic and microscopic joint scoring or early (mild) osteoarthritis. Differential expression of small non-coding RNAs was undertaken.
ORGANISM(S): Equus caballus 
2020-06-30 | E-MTAB-8409 | biostudies-arrayexpress
TranscriptomicsGene expression predictors of extension in oligoarticular juvenile idiopathic arthritis (JIA)
Children with oligoarticular JIA (arthritis in 4 or fewer joints) can either continue to have this mild form of arthritis (persistent oligoarticular JIA) or extend to a more sever form involving more than 4 joints (extended oligoarticular JIA) Synovial fluid mononuclear cell RNA was prepared from 21...
ORGANISM(S): Homo sapiens 
2009-03-04 | E-GEOD-15083 | biostudies-arrayexpress
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