Sort   by:  
 Page size 
GenomicsGenomewide occupancy of the synovial sarcoma-associated SYT-SSX2 oncoprotein in C2C12 myoblasts
Synovial sarcoma is a rare malignancy that is characterized by the presence of a chromosomal translocation t(X;18). This genetic abnormality results in the fusion of 2 transcriptional co-regulators, SYT and SSX, which have been shown to mediate transcriptional activation and repression, respectivel...
ORGANISM(S): Mus musculus 
2011-09-26 | E-GEOD-26564 | biostudies-arrayexpress
TranscriptomicsMetastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features [aCGH]
Synovial sarcoma (SynSa) is an aggressive mesenchymal tumor, comprising approximately 10% of all soft tissue sarcomas. Over half of SynSa patients develop metastasis or local recurrence, but the underlying molecular mechanisms of the aggressive clinical behavior remain poorly characterized. Sixty f...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-54183 | biostudies-arrayexpress
TranscriptomicsMetastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features [transcriptome]
Synovial sarcoma (SynSa) is an aggressive mesenchymal tumor, comprising approximately 10% of all soft tissue sarcomas. Over half of SynSa patients develop metastasis or local recurrence, but the underlying molecular mechanisms of the aggressive clinical behavior remain poorly characterized. Sixty f...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-54187 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synovial sarcoma-like tumors induced in a genetically engineered mouse model
Synovial sarcoma-like tumors were generated in mice by conditionally expressing the human t(X;18) translocation-derived SYT-SSX2 fusion protein. Using a Tamoxifen-inducible CreER system, we show here that sporadic expression of SYT-SSX2 across multiple tissue types leads to exclusive formation of sy...
ORGANISM(S): Mus musculus 
2009-04-24 | E-GEOD-14469 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of the human synovium in inflammatory arthritis
The study presents: - an optimized synovium dissociation protocol for single cell RNA-sequencing studies of the human synovium. The protocol enables the isolation of high yield of viable synovial cells from prospectively collected fresh synovial biopsies from patients with inflammatory arthritis wi...
ORGANISM(S): Homo sapiens 
2024-04-21 | E-MTAB-11791 | biostudies-arrayexpress
UnknownTargeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.
Not available
S-EPMC4972869 | biostudies-literature
TranscriptomicsSingle-cell transcriptomic profiling of 16 synovial sarcoma tumors
This study investigates the cellular heterogeneity of Synovial Sarcoma (SyS), an aggressive cancer defined by the SS18-SSX fusion oncogene and exhibiting diverse clinical behavior. We used single-cell RNA sequencing (scRNA-seq) on tumor samples from 16 patients to deconstruct this diversity at high ...
ORGANISM(S): Homo sapiens 
2025-10-16 | E-MTAB-15748 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
The human SYT-SSX fusion protein was expressed in a developmentally dependent fashion in murine myoblasts. Tumors harvested from mice in adolescence were compared to normal mouse skeletal muscle samples. Experiment Overall Design: Murine tumors were excised from affected mice for RNA extraction and...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6461 | biostudies-arrayexpress
GenomicsHDAC inhibitors in synovial sarcoma cells
Histone deacetylase (HDAC) inhibition has been shown in previous studies to disrupt the synovial sarcoma oncoprotein complex, resulting in apoptosis. To understand the molecular effects of HDAC inhibition, RNA-Seq transcriptome analysis was undertaken in six human synovial sarcoma cell lines. HDAC i...
EGAS00001002637 | EGA
TranscriptomicsSingle cell RNA and CITE sequencing of cells from synovial tissue biopsies of healthy donors, and Rheumatoid Arthritis (RA) patients with active disease or sustained clinical remission
The dataset includes the raw FASTQ files generated from the 10x Genomics Single Cell 3’ v3.1 experiments. For samples processed with TotalSeq Hashtag reagents, the corresponding hashtag oligonucleotide and condition annotations are provided as separate .csv files. The processed matrices contain filt...
ORGANISM(S): Homo sapiens 
2024-12-06 | E-MTAB-14213 | biostudies-arrayexpress
Sort   by:  
 Page size