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MetabolomicsA synthetic cell with integrated DNA self-replication and lipid biosynthesis

The emergence, organization, and persistence of cellular life are the result of the functional integration of metabolic and genetic networks. Here, we engineer phospholipid vesicles that can operate three essential functions, namely transcription-translation of a partial genome, self-replication ...

2026-02-02 | MTBLS13437 | MetaboLights
ProteomicsSynthetic bacterial vesicles combined with tumor exosomes as cancer immunotherapy
Bacterial outer membrane vesicles (OMV) have gained attention as a promising new cancer vaccine platform for efficiently provoking immune responses. However, OMV induce severe toxicity by activating the innate immune system. In this study, we applied a simple isolation approach to produce artificial...
ORGANISM(S): Escherichia coli 
2026-07-06 | PXD025421 | Pride
Outer membrane vesicles Cancer immunotherapy Synthetic bacterial vesicles 
ProteomicsDetoxified synthetic bacterial membrane vesicles as a platform of vaccines against bacteria and SARS-CoV-2
The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases. However, the inherent inflammatory nature of OMV limits their use as human vaccines. This study employed an engineered vesicle technology to develop sy...
ORGANISM(S): Pseudomonas aeruginosa 
2023-07-20 | PXD033690 | Pride
Vaccine delivery Label-free proteomics Synthetic bacterial vesicles Outer membrane vesicles (omv) 
UnknownSynthetic bacterial vesicles combined with tumour extracellular vesicles as cancer immunotherapy.
Not available
S-EPMC8254025 | biostudies-literature
ProteomicsEngineered synthetic eukaryotic vesicles as anti-inflammatory drug delivery system to target Myd88
Mesenchymal stem cells (MSC) secrete naturally extracellular vesicles (EV) with a regenerative profile, and an increasing number of studies have focused on the employment of EV for therapeutic drug delivery. However, EV are usually produced by the cells at low quantities and packed with unnecessary ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033512 | Pride
Mesenchymal stem cells Extracellular vesicles Therapeutic drug delivery Quantitative proteomics Human 
UnknownSynthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 to ameliorate osteoporosis.
Not available
S-EPMC10995478 | biostudies-literature
UnknownDetoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2.
Not available
S-EPMC10196325 | biostudies-literature
UnknownBacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Not available
S-EPMC10045439 | biostudies-literature
UnknownBacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells.
Not available
S-EPMC10184351 | biostudies-literature
UnknownSTING Agonist Drug Delivery by Bacterial Extracellular Vesicles Induces Synergistic Immuno-Oncology Responses and Efficient Inhibition of Tumour Growth.
Not available
S-EPMC12230345 | biostudies-literature
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