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MetabolomicsNarrow-spectrum resource-utilizing bacteria drive the stability of synthetic communities through enhancing metabolic interactions
The importance of synthetic microbial communities in agriculture is increasingly being recognized, but methods for constructing targeted synthetic communities using existing microbial resources remain limited. In this study, six plant beneficial bacterial strains with distinct capacities for utilizi...
2025-07-11 | MTBLS12572 | MetaboLights
MetabolomicsSynthetic Microbial Communities Improve Wheat Stem Base Rot and Promote Wheat Growth by Regulating Rhizosphere Microbial Communities

Background

Wheat crown rot (WCR) caused by Fusarium spp. lacks durable, sustainable control. Engineering the rhizosphere with defined synthetic microbial communities (SynComs) offers a route to combined disease suppression and growth promotion. We aimed to build a cross-kingdom SynCom and e...

2025-09-06 | MTBLS12945 | MetaboLights
MetabolomicsWild soybean rhizosphere microbiomes buffer continuous cropping obstacles in cultivated soybean via functional cross-kingdom synthetic communities

A cross-kingdom synthetic community (SSC) derived from wild soybean rhizosphere soil was constructed and inoculated onto cultivated soybeans suffering from continuous cropping obstacles. Root exudates from cultivated soybeans were collected before and after inoculation with the SSC via a hydropon...

2026-03-14 | MTBLS13803 | MetaboLights
MetabolomicsGrowth-Promoting Mechanisms of Synthetic Communities in Tomato and Wheat under Saline-Alkaline Stress
SynComs boosted saline-alkali resistance in tomato and wheat via host-specific reshaping of rhizosphere microhabitats and distinct core plant metabolic pathways.
2026-06-24 | MTBLS14847 | MetaboLights
MetabolomicsSilent guardians: Potentiators enhance synthetic microbiomes to combat co-contamination

Environmental co-contamination presents significant challenges. To tackle these, while microbial consortia offer advantages over single-strain approaches, such as functional redundancy and synergistic degradation, rationally designing effective synthetic microbiomes specifically for complex ...

2025-11-20 | MTBLS12809 | MetaboLights
MetabolomicsA synthetic community system for probing microbial interactions driven by exometabolites
Despite that most microorganisms live as part of community, we have modest knowledge about the interactions among microbial community members in nature, and the implications of those interactions for emergent community properties or ecosystem-relevant functions. To facilitate advances in understandi...
2017-10-26 | MTBLS525 | MetaboLights
MetabolomicsCross-kingdom synthetic microbiota suppresses wheat Fusarium crown rot by remodeling the rhizosphere microbiome and metabolome

Wheat is a major staple crop grown across the globe. Fusarium crown rot (FCR) of wheat, caused by Fusarium pseudograminearum, is a destructive soil-borne disease that lacks effective sustainable control measures. Here, we assembled a cross-kingdom synthetic microbial community (SMC) comprising Tr...

2025-09-06 | MTBLS12946 | MetaboLights
MetabolomicsMetabolic network construction reveals probiotic-specific colonization resistance in a synthetic small intestinal community

The gut microbiota is essential to host health. Probiotics can be used as a microbiota targeted therapy to improve host health. However, probiotic molecular mechanisms of action and probiotics targeting the small intestinal microbiota are often not elucidated. In this study, we construct a three ...

2024-09-26 | MTBLS7370 | MetaboLights
TranscriptomicsTemporal RNASeq of C. difficile cultured within synthetic multispecies biofilm relative to C. difficile monoculture biofilms.
This experiment was performed largely to capture the dynamic transcriptional changes occurring in C. difficile when cultured within a 9 species synthetic gut communal consortium over a 48 h time series when cultured as a biofilm in vitro.
ORGANISM(S): Clostridioides difficile 
2026-09-23 | E-MTAB-15646 | biostudies-arrayexpress
MetabolomicsDeciphering the in vitro interaction dynamics of synthetic mucosal-associated gut bacteria community

Maintaining the integrity of the mucus layer is essential for host health. Studies have implicated that reduced or abnormal mucus production may lead to intestinal inflammation. When dietary nutrients are abundant in the gut, mucin degradation by microbes decreases. However, when nutrient availab...

2025-07-18 | MTBLS11724 | MetaboLights
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