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MetabolomicsMicrobial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut
Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation and integrity of the intestinal epithelium. However, the production of SCFAs can vary widely between individuals consuming the same diet, with lower levels often associated ...
2026-05-26 | MTBLS2308 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
UnknownA primer on multiscale modelling of infectious disease systems.
Not available
S-EPMC6326222 | biostudies-literature
ModelsProctor2011_ProteinHomeostasis_NormalCondition
This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE2011; 6(7): e22038. doi:10.1371/journal.pone.0022038, Abstract: Neurodegeneration is a...
2024-09-02 | BIOMD0000000344 | BioModels
TranscriptomicsModelling Skeletal Muscle Ageing and Repair In Vitro
Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are associated with re...
ORGANISM(S): Homo sapiens 
2023-07-05 | E-MTAB-12248 | biostudies-arrayexpress
UnknownMathematical Modelling of Alternative Pathway of Complement System.
Not available
S-EPMC7024062 | biostudies-literature
ModelsCaravagna2010 - Tumour suppression by immune system
Tumour suppression by immune system through stochastic oscillations GiulioCaravagnaa Albertod’Onofriob PaoloMilazzoa RobertoBarbutia https://doi.org/10.1016/j.jtbi.2010.05.013 Abstract The well-known Kirschner–Panetta model for tumour–immune System interplay [Kirschner, D., Panetta, J.C., 1998. ...
2024-09-02 | BIOMD0000000912 | BioModels
Immuno-oncology 
ProteomicsOne-line-fits-all: a knockdown strategy for rapid, generic and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal-muscle
Humanized 3D-tissue-engineered-skeletal-muscles (3D-TESMs) offer advanced disease modelling, but their application often require isogenic controls and involves laborious and time consuming methodology. Here, by combining 3D-TESM and shRNA approaches, we developed a “one-line-fits-all” disease modell...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD042227 | Pride
Skeletal-muscle-on-a-chip Disease modelling 3d-organ-on-a-chip Duchenne’s muscular dystrophy Dystrophin Lgmd2a Calpain-3 Genetic knockdown Tissue engineering 
GenomicsDeep dynamical modelling of developmental trajectories with temporal transcriptomics [SCIFATE_PILOT_DATA]
Deep dynamical modelling of developmental trajectories with temporal transcriptomics [SCIFATE_PILOT_DATA]
PRJNA991523 | ENA
GenomicsDeep dynamical modelling of developmental trajectories with temporal transcriptomics [EXPERIMENT_DATA]
Deep dynamical modelling of developmental trajectories with temporal transcriptomics [EXPERIMENT_DATA]
PRJNA991513 | ENA
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