Sort   by:  
 Page size 
MetabolomicsA Combined Metabolomic and Proteomic Investigation of the Effects of a Failure to Express Dystrophin in the Mouse Heart
Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. ...
2017-03-14 | MTBLS256 | MetaboLights
ProteomicsDystrophin domains R4-15 and R20-23
Goal was to assess protein linkers between microtubules and dystrophin (specifically dystrophin regions R4-15 and R20-23). Two paired 10-plex TMT experiments were used to compare sixteen unique Dystrophin Glycoprotein Complex (or microtubule) enrichments (four genotypes, each with n=4) plus four poo...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-21 | PXD021088 | Pride
Micro-dystrophin Dystrophin glycoprotein complex Mice Dystrophin Microtubules 
TranscriptomicsTranscription profiling of mouse dystrophin-deficient and dystrophin and utrophin double-deficient animalse crossed with mice with full-length hDMD genes
Crossing of hDMD mice that contain the full-length 2.3 Mb hDMD gene were crossed with dystrophin-deficient mdx mice and dystrophin and utrophin double-deficient mdx x utrn-/- mice resulted in a full rescue of the dystrophic features of these mice, as concluded from histological analysis. Analysis on...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6790 | biostudies-arrayexpress
TranscriptomicsTranscriptome of mouse primary muscle cultures upon dystrophin knockdown by RNAi.
Dystrophin was knocked down in primary muscle cultures prepared from C57Bl/10 neonate mice using siRNA targeting dystrophin. Also in parallel, primary muscle cultures treated with siRNA targting luciferase were used as controls. The experiment was designed so that the same cell populations were used...
ORGANISM(S): Mus musculus 
2010-12-21 | E-GEOD-20548 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mdx animals expressing high levels of utrophin therapeutic implications for DMD
Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disorder caused by dystrophin deficiency. Previous work suggested that increased expression of the dystrophin-related protein utrophin in the mdx mouse model of DMD can prevent dystrophic pathophysiology. Physiological tests showed that t...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7187 | biostudies-arrayexpress
ProteomicsDystrophin - Human Dystrophin Structural Changes upon Binding to Anionic Membrane Lipids
Mapping of dystrophin-lipid interactions by mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD007716 | Pride
Click-chemistry Phosphlipid Dystrophin 
TranscriptomicsTranscription profiling of extraocular, hindlimb and cardiac muscles from dKO and MDX mice
Comparison by expression profiling of tissue from dKO (utrophin/dystrophin-deficient) and MDX mice at 8 weeks of age. Independent triplicate analyses/strain were done for extraocular, hindlimb, and cardiac muscle.
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-1463 | biostudies-arrayexpress
ProteomicsProtein Identification and Post-translational Analysis of DMD and its associated Proteins in H19-proficient and -deficient Cells
Dystrophin proteomic regulation in Muscular Dystrophies (MD) remains unclear. We report that a long noncoding RNA (lncRNA) H19 associates with dystrophin. To investigate the biological roles of this interaction in vivo, we performed mass spectrometry analysis of dystrophin and its associated protein...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-19 | PXD020566 | Pride
Nifenazone Mouse Dystrophin Dmd Agr-h19 Lc-ms Bmd C2c12 H19 
TranscriptomicsLoss of full-length dystrophin expression causes major cell-autonomous abnormalities in proliferating myoblasts
Duchenne muscular dystrophy (DMD) is a severely debilitating and incurable neuromuscular disease. Its conspicuous feature is the absence of dystrophin in myofibers and therefore most therapeutic approaches focus on some form of its re-expression there. However, increasing body of evidence points at ...
ORGANISM(S): Mus musculus 
2022-09-14 | E-MTAB-10322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse extraocular and hindlimb muscle to determine gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56
Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain.
ORGANISM(S): Mus musculus 
2007-10-09 | E-GEOD-1472 | biostudies-arrayexpress
Sort   by:  
 Page size