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TranscriptomicsTranscription profiling of human monocytes from pre-and post-menopausal women with high or low bone mineral density
Monocytes were isolated from 30 ml of whole blood from each of 19 women, 10 with high BMD and 9 with low BMD, using monocyte negative isolation kit from Dynal Biotech Inc. Total RNA was extracted from monocytes using Qiagen RNeasy Mini Kit. Targets were produced for each subject using standard Affym...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2208 | biostudies-arrayexpress
ProteomicsLC-MSMS of postmenopausal with low BMD
Postmenopausal osteoporosis (PMOP) is a major global public health concern and older women are more susceptible to experiencing fragility fractures. Our study investigated the associations between circulating proteins with bone mineral density (BMD) in postmenopausal women with or without low BMD (o...
ORGANISM(S): Homo sapiens (Human) 
2020-04-27 | PXD017804 | Pride
Human Lc-msms Postmenopausal Low bmd Plasma 
GenomicssnRNAseq RAT HEART WT BMD and DMD 12months
snRNAseq RAT HEART WT BMD and DMD 12months
PRJNA975146 | ENA
ProteomicsProteome analysis of skeletal muscle of DMD, BMD and WT pigs
Duchenne muscular dystrophy is a fatal X-linked disease caused by mutations in the DMD gene, leading to the absence of dystrophin and progressive degeneration of skeletal and cardiac muscles. Pigs lacking DMD exon 52 (DMDΔ52) are a clinically severe model for DMD, mimicking molecular, functional, an...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-03-12 | PXD064879 | Pride
Duchenne muscular dystrophy Pig model Becker muscular dystrophy Muscle 
TranscriptomicsTranscription profiling of human B-lymphocytes from postmenopausal female smokers with high or low bone mineral density
B cells produce important cytokines regulate bone metabolism. We comparison gene expression patterns of circulating B cells in blood from 20 postmenopausal female smokers with low or high bone mineral density (BMD): 10 low BMD vs. 10 high BMD. In total 17 differentially expressed genes were identifi...
ORGANISM(S): Homo sapiens 
2009-10-20 | E-GEOD-13850 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers from female C57BL/6J and B6.C3H-6T mice to study differential gene expression in the two strains.
Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Tr...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5959 | biostudies-arrayexpress
Genomics
Brain Metabolic DNA (BMD)
PRJNA608649 | ENA
TranscriptomicsThe MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer
Well-defined, closed breeding populations coupled with excessive disease predispositions among purebred domestic dog breeds offer unique advantages to genetic studies of disease susceptibility. Advantages offered by canine population substructure, combined with similarity to human disease in terms o...
ORGANISM(S): Canis lupus familiaris 
2012-07-02 | E-GEOD-38011 | biostudies-arrayexpress
GenomicsIdentification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci
Identification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci
PRJNA776822 | ENA
TranscriptomicsIdentification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci
Osteoporosis, characterized by low bone mineral density (BMD), is the most common complex disease affecting bone and constitutes a major societal health problem. Genome-wide association studies (GWASs) have identified over 1100 associations influencing BMD. It has been shown that perturbations to lo...
ORGANISM(S): Homo sapiens 
2021-11-04 | GSE186922 | GEO
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