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MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
MetabolomicsIntegrative Ophthalmology of Traditional Chinese and Western Medicine
Research directions include prevention and control of myopia, intervention against age-related macular degeneration, ophthalmic optical research, and research on ophthalmology-oriented artificial intelligence technologies.
2026-07-21 | MTBLS15095 | MetaboLights
MetabolomicsIntegrative Ophthalmology of Traditional Chinese and Western Medicine
Research directions include prevention and control of myopia, intervention against age-related macular degeneration, ophthalmic optical research, and research on ophthalmology-oriented artificial intelligence technologies.
2026-07-21 | MTBLS15109 | MetaboLights
MetabolomicsIdentification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine

INTRODUCTION: Bitter melon (Momordica charantia, Cucurbitaceae) is a popular edible medicinal plant, which has been used as a botanical dietary supplement for the treatment of diabetes and obesity in Chinese folk medicine. Previously, our team has proved that cucurbitanes triterp...

2019-10-24 | MTBLS701 | MetaboLights
MetabolomicsMass spectrometry based metabolomics for in vitro systems pharmacology: Pitfalls, challenges, and computational solutions

INTRODUCTION: Mass spectrometry based metabolomics has become a promising complement and alternative to transcriptomics and proteomics in many fields including in vitro systems pharmacology. Despite several merits, metabolomics based on liquid chromatography mass spectrometry (LC...

2017-08-23 | MTBLS401 | MetaboLights
MetabolomicsAdaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we ...

2022-04-22 | MTBLS4161 | MetaboLights
MetabolomicsUntargeted Metabolomics Study of Cur-EGCG Self-Assembled Nanoparticle Systems in Intervening WSSV Infection in Crayfish
This study employed Untargeted LC-MS/MS metabolomics to analyze changes in the metabolic profile of crayfish following WSSV infection after intervention with the Cur-EGCG self-assembled nanoscale system (CE SA). The experiment included WSSV and CE SA treatment groups. Through multivariate statistica...
2026-10-04 | MTBLS15908 | MetaboLights
MetabolomicsA systems analysis with “simplified source-sink model” reveals metabolic reprogramming in a pair of source-to-sink organs during early fruit development in tomato by LED light treatments
Tomato (Solanum lycopersicum) is a model crop for studying development regulation and ripening in flesh fruits and vegetables. Supplementary light to maintain the optimal light environment can lead to the stable growth of tomatoes in greenhouses and areas without sufficient daily light integral. Tec...
2018-09-27 | MTBLS699 | MetaboLights
TranscriptomicsA comparative systems analysis of polysaccharide-elicited responses in Neurospora crassa reveals carbon source-specific cellular adaptations
Filamentous fungi are powerful producers of hydrolytic enzymes for the deconstruction of plant cell wall polysaccharides. However, the central question of how these sugars are perceived in the context of the complex cell wall matrix remains largely elusive. To address this question in a systematic f...
ORGANISM(S): Neurospora crassa OR74A 
2013-11-27 | E-GEOD-42692 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Escherichia coli Nissle 1917 strains modified to produce different amounts of the bacteriocin microcin C
A popular strategy for enhancing the antibacterial properties of probiotic bacteria is to retrofit them with the ability to overproduce heterologous bacteriocins. This is often achieved from strong, non-native promoters. How the dysregulated overproduction of heterologous bacteriocins affects the fi...
ORGANISM(S): Escherichia coli 
2023-06-30 | E-MTAB-13078 | biostudies-arrayexpress
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