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TranscriptomicsSmall RNA-Seq Reveals similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia
We aimed to identify miRNAs and pathways specifically deregulated in adolescent and young adult (AYA) T-ALL patients. Small RNA-seq showed no major differences between AYA and pediatric T-ALL, but it revealed downregulation of miR-143-3p in T-ALL patients. Prediction algorithms identified several kn...
ORGANISM(S): Homo sapiens 
2022-09-06 | E-MTAB-11987 | biostudies-arrayexpress
TranscriptomicsComprehensive investigation of miRNome identifies novel candidate miRNA-mRNA interactions implicated in T-cell acute lymphoblastic leukemia
The aim of the study was to characterize the landscape of miRNA expression in 34 samples of pediatric T-cell acute lymphoblastic leukemia (T-ALL) and to identify miRNAs differentially expressed between T-ALL and normal mature T lymphocytes (5 samples).
ORGANISM(S): Homo sapiens 
2019-01-28 | E-MTAB-7446 | biostudies-arrayexpress
UnknownRegeneration of Peripheral Blood T-Cell Subpopulations in Children After Completion of Acute Lymphoblastic Leukemia Treatment.
Not available
S-EPMC12652639 | biostudies-literature
UnknownLack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL.
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S-EPMC3913939 | biostudies-literature
UnknownGαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells.
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S-EPMC6400544 | biostudies-literature
UnknownGenetic hallmarks and clinical implications of chromothripsis in childhood T-cell acute lymphoblastic leukemia.
Not available
S-EPMC11518979 | biostudies-literature
UnknownComprehensive Investigation of miRNome Identifies Novel Candidate miRNA-mRNA Interactions Implicated in T-Cell Acute Lymphoblastic Leukemia.
Not available
S-EPMC6372882 | biostudies-literature
UnknownMultiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: Focus on miR-363-3p and promoter methylation.
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S-EPMC9796420 | biostudies-literature
UnknownIRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.
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S-EPMC3721331 | biostudies-literature
UnknownAdvantages and Limitations of SNP Array in the Molecular Characterization of Pediatric T-Cell Acute Lymphoblastic Leukemia.
Not available
S-EPMC7379740 | biostudies-literature
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