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ProteomicsComplexome profiling of heart mitochondria from mouse expressing alternative oxidase
Ciona intestinalis alternative oxidase (AOX) is a mitochondrial respiratory enzyme that acts as an alternative electron sink for ubiquinol (reduced quinone) when the cytochrome bc1 complex (complex III) and/or cytochrome c oxidase (complex IV) are inhibited or impaired (El-Khoury et al., 2014). AOX ...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-13 | PXD014016 | Pride
Alternative oxidase Mitochondria Lc-msms Complexome profiling 
TranscriptomicsTranscriptomics study on the effect of alternative oxidase expression in Bcs1l mutant (S78G) mice (Mus musculus)
The dataset contains 72 RNA-seq samples obtained from adult (P150) C57BL/6JCrl mice. Samples are from total heart, liver and kidney tissue. Four different genotypes are included in the data: 1) wild type, 2) transgenic Ciona intestinalis AOX in Rosa26 locus (Szibor et al. 2017, DOI: 10.1242/dmm.0278...
ORGANISM(S): Mus musculus 
2018-11-16 | E-MTAB-7416 | biostudies-arrayexpress
ProteomicsProteome analysis of pig heart tissue to study the molecular consequences of hyperbaric oxygen treatment
The overall goal of the project was to confirm the presence of different energetic states of mitochondrial subpopulations depending on their subcellular localization within cardiomyocytes, i.e., subsarcolemmal (SSM) and interfibrillar mitochondria (IFM). Here we analysed proteomic changes upon treat...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-22 | PXD047678 | Pride
Mitochondria Hyperbaric oxygen 
ProteomicsComplexome profiling of mitochondrial protein complexes from pig heart to study the molecular consequences of hyperbaric oxygen treatment
The overall goal of the project was to confirm the presence of different energetic states of mitochondrial subpopulations depending on their subcellular localization within cardiomyocytes, i.e., subsarcolemmal (SSM) and interfibrillar mitochondria (IFM). At the same time, we aimed to elucidate possi...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-22 | PXD035554 | Pride
Lc-ms/ms Oxidative phosphorylation system Mitochondrial respiratory complex assembly Complexome profiling 
TranscriptomicsIdentification of right heart-enriched genes in a murine model of chronic outflow tract obstruction
The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a high...
ORGANISM(S): Mus musculus 
2011-07-07 | E-GEOD-30428 | biostudies-arrayexpress
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