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GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
UnknownIdentifying structure-absorption relationships and predicting absorption strength of non-fullerene acceptors for organic photovoltaics.
Not available
S-EPMC9277517 | biostudies-literature
UnknownPcsk5 is required in the early cranio-cardiac mesoderm for heart development.
Not available
S-EPMC5407003 | biostudies-literature
UnknownBiallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling.
Not available
S-EPMC4048740 | biostudies-literature
UnknownFurin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.
Not available
S-EPMC3123046 | biostudies-literature
UnknownTagged mutagenesis by efficient Minos-based germ line transposition.
Not available
S-EPMC2798303 | biostudies-literature
TranscriptomicsHIC2 is a novel dosage-dependent regulator of cardiac development within the distal 22q11 deletion syndrome region
Rationale: 22q11 deletion syndrome arises from recombination between low copy repeats on chromosome 22. Typical deletions result in hemizygosity for TBX1 associated with congenital cardiovascular disease. Deletions distal to the typically deleted region result in a similar cardiac phenotype but lack...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-56430 | biostudies-arrayexpress
UnknownFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.
Not available
S-EPMC5004903 | biostudies-literature
UnknownHes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome.
Not available
S-EPMC2877781 | biostudies-literature
UnknownArtefacts in Volume Data Generated with High Resolution Episcopic Microscopy (HREM).
Not available
S-EPMC8615656 | biostudies-literature
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