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TranscriptomicsS-adenosylmethionine (SAM) changes DNA methylation patterns in prostate cancer cells
Genome-wide DNA methylation profiling of human PC3 invasive prostate cancer cell line treated with vehicle control (SAH, S-adenosylhomocysteine) and with SAM (S-adenosylmethionine) as well as of untreated human LNCaP non-invasive prostate cancer cell line. The Illumina Infinium 450k Human DNA Methyl...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-62053 | biostudies-arrayexpress
TranscriptomicsDNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm
Background: Prenatal maternal stress (PNMS) predicts a wide variety of behavioral and physical outcomes in the offspring. Although epigenetic processes may be responsible for PNMS effects, human research is hampered by the lack of experimental methods that parallel controlled animal studies. Disaste...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-72354 | biostudies-arrayexpress
TranscriptomicsAnkyrin-3 as a Molecular Marker of Early Life Stress and Vulnerability to Psychiatric Disorders
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2016-07-06 | E-GEOD-84028 | biostudies-arrayexpress
GenomicsDNA methylation at transcription start sites blocks TBP binding and transcription onset by RNApolII [ChIPbisSeq]
We report the application of ChIP bisulfite sequencing (ChIPbisSeq) to establish the methylation state of DNA bound to RNApol2 phosphorylated in Ser5 (RNAPol2Ser5) in the mouse cortex. We first profiled the RNAPol2Ser5 binding using regular ChIPSeq from 45 million raw read pairs (31 million unique p...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-60657 | biostudies-arrayexpress
UnknownSynergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.
Not available
S-EPMC4216057 | biostudies-literature
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving and treatments with DNA methylation modifying drugs
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine, were subjected to 30 withdrawal days, were treated with aCSF, RG108 or SAM and were subjected to extinction tests. The groups consist of: 1. Rats that self-administered cocaine for 10 days and that were subjected...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66347 | biostudies-arrayexpress
TranscriptomicsDNA methylation at transcription start sites blocks TBP binding and transcription onset by RNApolII [MeDIP]
We measured the methylation levels of gene promoters of cerebral cortex of mice. We used MeDIP-array, immunoprecipitating genomic DNA with an antibody against methylated DNA and measuring methylation levels using custom arrays. The input DNA was used as control. triplicates of frontal cortex DNA po...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-60656 | biostudies-arrayexpress
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine and were subjected to 1 or 30 withdrawal days with or without extinction tests. The groups consist of 1. Saline rats (Sal.) 2. Rats that self-administered cocaine for 10 days and that were subjected to a withdrawal...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66348 | biostudies-arrayexpress
TranscriptomicsEarly life adversity alters normal sex-dependent developmental dynamics of DNA methylation in rhesus monkeys
This study mapped the genome wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through two years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles ev...
ORGANISM(S): Macaca mulatta 
2016-07-06 | E-GEOD-84024 | biostudies-arrayexpress
TranscriptomicsDifferential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression
Animal and human studies suggest that inflammation is associated with behavioral disorders including aggression. We have recently shown that physical aggression of boys during childhood is strongly associated with reduced plasma levels of cytokines IL-1a, IL-4, IL-6, IL-8 and IL-10, later in early a...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-47193 | biostudies-arrayexpress
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