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TranscriptomicsImmunoregulatory actions of T cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20523 | biostudies-arrayexpress
GenomicsClonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis
Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis
PRJNA846154 | ENA
GenomicsDissection of the T-cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T-cell repertoire
Dissection of the T-cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T-cell repertoire
PRJNA896975 | ENA
TranscriptomicsEffect of human breast tumor supernatant on normal CD4+ T cells (Confirmation Set SN)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36766 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD4+ T cells infiltrating human breast cancer (Discovery Set)
CD4+ helper T (Th) cells are critical regulators of immune responses but their role in breast cancer is currently unknown. This work aims to characterize Th cells infiltrating invasive primary human breast tumors, analyze the influence by the tumor microenvironment and identify Th cell specific prog...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-36765 | biostudies-arrayexpress
ProteomicsSpatial proteomics of T-cell infiltrates in melanoma reveals differential regulation of TOR signaling
The tumor microenvironment determines the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. To better understand and assess targetable promising biological processes that s...
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD035502 | Pride
Spatial proteomics T cell infiltrate Melanoma Immune checkpoint inhibition Lc-ms/ms 
GenomicsT cells expressing modified Fc receptor infiltrate solid tumors and provide long-term anti-tumor protection
T cells expressing modified Fc receptor infiltrate solid tumors and provide long-term anti-tumor protection
PRJNA1096041 | ENA
GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
TranscriptomicsTranscriptome and Molecular Pathways Analysis of CD4 T-Cells from Young NOD Mice
Type 1 diabetes is a multigenic disease caused by T-cell mediated destruction of the insulin producing β-cells. Although conventional (targeted) approaches of identifying causative genes have advanced our knowledge of this disease, many questions remain unanswered. Using a whole molecular systems st...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-46600 | biostudies-arrayexpress
GenomicsPD-1 prevents pathogenicity of effector CD8 T cells that infiltrate skin under homeostatic conditions
PD-1 prevents pathogenicity of effector CD8 T cells that infiltrate skin under homeostatic conditions
PRJNA950401 | ENA
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