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In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed SILAC approach, we investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activat...
ORGANISM(S): Homo sapiens (Human) 
2020-06-09 | PXD017159 | Pride
Dynamics in protein translation sustaining T cell preparedness
In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed SILAC approach, we investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activat...
ORGANISM(S): Homo sapiens 
2020-05-07 | GSE147229 | GEO
The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. The process by which the commensal microbiota influence the host immune system is poorly understood. We show here that colonization o...
ORGANISM(S): Mus musculus 
Basal level of ATF4 promotes T cell readiness for activation-induced proliferation [RNA-seq]
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