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TranscriptomicsTranscription profiling of mouse vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)
Analysis of in vivo antigen-specific (LCMV-specific, SMARTA TCR transgenic) follicular helper CD4 T cells (CXCR5high),versus non-follicular helper CD4 T cells (CXCR5low), eight days after viral infection. A paper including data analysis of these experiments has been accepted for publication (Robert ...
ORGANISM(S): Mus musculus 
2009-08-07 | E-GEOD-16697 | biostudies-arrayexpress
TranscriptomicsExpression Data from WT and Sh2d1a-/- in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)
CD4 T cell help is critical for both the generation and maintenance of germinal centers, and T follicular helper (TFH) cells are the CD4 T cell subset required for this process. SAP (SH2D1A) expression in CD4 T cells is essential for germinal center development. However, SAP-deficient mice have only...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21379 | biostudies-arrayexpress
GenomicsFunctional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells
Follicular T helper cells (Tfh) provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM-associated Protein (SAP) prevent GC formation due to defective T-B cell interactions, yet effects on Tfh cell differentiation remain unclear. We describe the in vitro differe...
ORGANISM(S): Mus musculus 
2012-01-05 | E-GEOD-32864 | biostudies-arrayexpress
GenomicsEarly T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating ...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-33802 | biostudies-arrayexpress
GenomicsCytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation
T helper (Th) cells control host defense to pathogens. IL 12R expression is required for Th1, IL-4RM-NM-1 for Th2, and IL-6RM-NM-1/gp130 for Th17 differentiation to allow responsiveness to IL-12, IL-4, and IL-6, respectively. IL-2 via STAT5 controls Th2 differentiation by regulating the Th2 cytokine...
ORGANISM(S): Homo sapiens 
2011-04-24 | E-GEOD-27158 | biostudies-arrayexpress
TranscriptomicsGlobal Transcriptome Analysis and Enhancer Landscape of Human Primary T Follicular Helper and T Effector Lymphocytes (RNA-Seq)
T follicular helper (Tfh) cells are a subset of CD4+ T helper (Th) cells that migrate into germinal centers and promote B cell maturation into memory B and plasma cells. Tfh cells are necessary for promotion of protective humoral immunity following pathogen challenge, but when aberrantly regulated, ...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-58596 | biostudies-arrayexpress
GenomicsTranscription factor Achaete-Scute homologue 2 initiates T follicular helper cell development [ChIP-Seq]
In immune responses, activated T cells migrate to B cell follicles and develop to T follicular helper (Tfh) cells, a new subset of CD4+ T cells specialized in providing help to B lymphocytes in the induction of germinal centers 1-3. Although Bcl6 has been shown to be essential in Tfh cell function, ...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52839 | biostudies-arrayexpress
GenomicsDiscrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during Helper T Cell Differentiation (ChIP-Seq)
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full c...
ORGANISM(S): Mus musculus 
2010-06-18 | E-GEOD-22104 | biostudies-arrayexpress
GenomicsType I Interferon induces binding of STAT1 to Bcl6: Divergent Roles of STAT-family transcription factors in the T follicular helper cell genetic program
CD4+ T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although seve...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-51531 | biostudies-arrayexpress
TranscriptomicsCytokine-independent detection of antigen-specific germinal center T follicular helper (Tfh) cells in immunized non-human primates using a live cell Activation Induced Marker (AIM) technique
A range of current candidate AIDS vaccine regimens are focused on generating protective HIV neutralizing antibody responses. Many of these efforts rely on the rhesus macaque animal model. Understanding how protective antibody responses develop and how to increase their efficacy are both major knowle...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-81382 | biostudies-arrayexpress
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