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TranscriptomicsTranscription profiling of human Hela cells infected with Trypanosoma cruzi
As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm of nucleated host cells, infection with this parasite is highly likely to affect host cells. We performed an exhaustive transcriptome analysis of T. cruzi-infected HeLa cells using an oligonucleotide microarra...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-7047 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of the Trypanosoma cruzi life-cycle
To generate a high quality, annotated gene expression database of T. cruzi trypomastigotes(TRP), amastigotes (AMA), epimastigotes (EPI), and metacyclic trypomastigotes (MET). The global assessment of transcript abundances in each life-cycle stage of T. cruzi will identify stage-regulated genes and p...
ORGANISM(S): Trypanosoma cruzi 
2010-05-15 | E-GEOD-14641 | biostudies-arrayexpress
TranscriptomicsWidespread, focal copy number variations (CNV) in Trypanosoma cruzi strains
Trypanosoma cruzi is a protozoan parasite and the etiologic agent of Chagas disease, an important public health problem in Latin America. T. cruzi is diploid, almost exclusively asexual, and displays an extraordinarily diverse population structure both genetically and phenotypically. Yet, to date ...
ORGANISM(S): Trypanosoma cruzi 
2011-08-05 | E-GEOD-23576 | biostudies-arrayexpress
TranscriptomicsExpression data from human primary fibroblasts treated with Trypanosoma cruzi-conditioned medium
The intracellular pathogen Trypanosoma cruzi secretes an activity that blocks TGF-β-dependent induction of connective tissue growth factor (CTGF/CCN2). Here, we address the mechanistic basis for T. cruzi-mediated interference of CTGF/CCN2 expression by examining host cell signaling pathways and the...
ORGANISM(S): Homo sapiens 
2011-09-08 | E-GEOD-16416 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of T. cruzi infection : 24 hours
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-09-26 | E-SMDB-1560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of T. cruzi : parasite-conditioned medium
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-09-26 | E-SMDB-1563 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of T. cruzi, parasite control RNA
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-09-26 | E-SMDB-1561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of T. cruzi : 2-6 hours infection
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-09-26 | E-SMDB-1562 | biostudies-arrayexpress
TranscriptomicsImmediate/Early Response to Trypanosoma cruzi Infection Involves Minimal Modulation of Host Cell Transcription
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays con...
ORGANISM(S): Homo sapiens 
2005-10-20 | E-GEOD-3476 | biostudies-arrayexpress
ProteomicsGlobal changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix.
Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of t...
ORGANISM(S): Trypanosoma cruzi cruzi 
2021-09-09 | PXD016313 | Pride
Histones Tyrosine nitration Trypanosoma cruzi Extracellular matrix 
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