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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
MetabolomicsMg2+ in drinking water exacerbates Salmonella Typhimurium T6SS-mediated intestinal bacterial competition through affecting metabolic reprogramming

By establishing a model of enteritis in mice infected with Salmonella Typhimurium, this study investigates the effects of ion concentration in drinking water on intestinal metabolites and microbiota structure in mice, as well as its influence on pathogen susceptibility and the host-patho...

2025-12-30 | MTBLS12690 | MetaboLights
UnknownInsights into dynamics and gating properties of T2SS secretins.
Not available
S-EPMC10550240 | biostudies-literature
UnknownLeaf microbiome dysbiosis triggered by T2SS-dependent enzyme secretion from opportunistic Xanthomonas pathogens.
Not available
S-EPMC10769872 | biostudies-literature
UnknownCommensal lifestyle regulated by a negative feedback loop between Arabidopsis ROS and the bacterial T2SS.
Not available
S-EPMC10784570 | biostudies-literature
UnknownDirect interactions between the secreted effector and the T2SS components GspL and GspM reveal a new effector-sensing step during type 2 secretion.
Not available
S-EPMC6302157 | biostudies-literature
ProteomicsCrosslinking of XcpHI of T2SS
The type IV filament superfamily comprises widespread membrane-associated polymers in prokaryotes. The Type II secretion system (T2SS), a virulence pathway in many pathogens, belongs to this superfamily. A knowledge gap in understanding of the T2SS is the molecular role of a small pseudopilin protei...
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2021-02-19 | MSV000086916 | MassIVE
ProteomicsCrosslinking of XcpHIJK of T2SS
The type IV filament superfamily comprises widespread membrane-associated polymers in prokaryotes. The Type II secretion system (T2SS), a virulence pathway in many pathogens, belongs to this superfamily. A knowledge gap in understanding of the T2SS is the molecular role of a small pseudopilin protei...
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2021-02-19 | MSV000086915 | MassIVE
UnknownOld role with new feature: T2SS ATPase as a cyclic-di-GMP receptor to regulate antibiotic production.
Not available
S-EPMC11107153 | biostudies-literature
TranscriptomicsThe transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages
Analysis of the human monocyte-derived macrophage (hMDM) transcriptional response to L. pneumophila infection at 8 hours post-infection We used microarrays to probe the hMDM transcriptional response to wild type L. pneumophila AA100 infection and its isogenic ankB and T2SS mutants. We identified up...
ORGANISM(S): Homo sapiens 
2014-09-19 | E-GEOD-61535 | biostudies-arrayexpress
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